苯磺酸氨氯地平 111470-99-6上海惠诚生物
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上海惠诚生物特色产品：糖类标准品，脂肪酸标准品，花青素标准品，类胡萝卜素,人乳寡糖等食品分析标准品。
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| Cat. Number |
A5044
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| Chemical Name |
苯磺酸氨氯地平,Amlodipine besylate
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| CAS Number |
111470-99-6
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| Mol. Formula |
C20H25ClN2O5 • C6H5SO3H
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| Mol. Weight |
567.06
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| Qty 1 |
1g
|
| Qty 2 |
10g
|
| Appearance |
Almost White Crystal Powder
|
| Synonym |
Amlodipine Benzenesulfonate, Amlor, Istin, Monopina, Norvasc,2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4- dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzenesulfonate
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| Melting Pt. |
195-204°C
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| Solubility |
Slightly soluble in water. Sparingly soluble in ethanol. soluble in DMSO(113mg/ml)
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| Storage condition |
Ambient
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| References |
Amlodipine is a dihydropyridine L-type Ca2+ channel blocker that exhibits antihypertensive, anti-anginal, and vasodilatory activities. Amlodipine is clinically used to treat hypertension and angina as it induces relaxation of arterial smooth muscles, decreases blood pressure, and increases blood flow to the heart. Amlodipine also inhibits acid sphingomyelinase (FIASMA), which is involved in programmed cell death. Additionally, this compound improves smooth muscle hypertrophy and collagen deposition, preventing arterial remodeling in hypertensive rats. 参考文献： Chen JL, Shang QH, Hu W, et al. Role of TGF-β1/Smads pathway in carotid artery remodeling in renovascular hypertensive rats and prevention by Enalapril and Amlodipine. J Geriatr Cardiol. 2012 Jun;9(2):185-91. PMID: 22916067. Kornhuber J, Tripal P, Reichel M, et al. Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): a novel pharmacological group of drugs with broad clinical applications. Cell Physiol Biochem. 2010;26(1):9-20. PMID: 20502000. Wang JG. A combined role of calcium channel blockers and angiotensin receptor blockers in stroke prevention. Vasc Health Risk Manag. 2009;5:593-605. PMID: 19688100. |
上海惠诚生物科技有限公司 “惠质产品，挚诚服务”，上海惠诚生物科技有限公司，位于上海市徐汇区，汇集国内生物医药领域资源与人脉优势，立足于石化、电子、工业、制药、生命科学、政府、教育及商业实验室等众多研究领域，为广大科研用户提供科学仪器，试剂耗材等专业科研产品服务,服务电话17715331663.QQ:2303607288
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