标准品/对照品

苯磺酸氨氯地平 111470-99-6上海惠诚生物

基本信息
产品名称:
苯磺酸氨氯地平 111470-99-6上海惠诚生物
英文名称:
Amlodipine besylate
国产/进口:
进口
产地/品牌:
LKT
型号:
10g
参考报价:
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总点击数:
41
更新日期:
2020-03-30
产品类别:

性能参数
苯磺酸氨氯地平 英文名: Amlodipine besylate,CAS号:111470-99-6,分子式:C20H25ClN2O5 • C6H5SO3H,分子量:567.06 上海惠诚生物现货提供
上海惠诚生物科技有限公司 “惠质产品,挚诚服务”。
上海惠诚生物特色产品:糖类标准品,脂肪酸标准品,花青素标准品,类胡萝卜素,人乳寡糖等食品分析标准品。
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Cat. Number
A5044
Chemical Name
苯磺酸氨氯地平,Amlodipine besylate
CAS Number
111470-99-6
Mol. Formula
C20H25ClN2O5 • C6H5SO3H
Mol. Weight
567.06
Qty 1
1g
Qty 2
10g
Appearance
Almost White Crystal Powder
Synonym
Amlodipine Benzenesulfonate, Amlor, Istin, Monopina, Norvasc,2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4- dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzenesulfonate
Melting Pt.
195-204°C
Solubility
Slightly soluble in water. Sparingly soluble in ethanol. soluble in DMSO(113mg/ml)
Storage condition
Ambient
References

Amlodipine is a dihydropyridine L-type Ca2+ channel blocker that exhibits antihypertensive, anti-anginal, and vasodilatory activities. Amlodipine is clinically used to treat hypertension and angina as it induces relaxation of arterial smooth muscles, decreases blood pressure, and increases blood flow to the heart. Amlodipine also inhibits acid sphingomyelinase (FIASMA), which is involved in programmed cell death. Additionally, this compound improves smooth muscle hypertrophy and collagen deposition, preventing arterial remodeling in hypertensive rats.

参考文献:

Chen JL, Shang QH, Hu W, et al. Role of TGF-β1/Smads pathway in carotid artery remodeling in renovascular hypertensive rats and prevention by Enalapril and Amlodipine. J Geriatr Cardiol. 2012 Jun;9(2):185-91. PMID: 22916067.

Kornhuber J, Tripal P, Reichel M, et al. Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): a novel pharmacological group of drugs with broad clinical applications. Cell Physiol Biochem. 2010;26(1):9-20. PMID: 20502000.

Wang JG. A combined role of calcium channel blockers and angiotensin receptor blockers in stroke prevention. Vasc Health Risk Manag. 2009;5:593-605. PMID: 19688100.

公司简介

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