抗体

PCSK9 鼠单克隆抗体

基本信息
产品名称:
PCSK9 鼠单克隆抗体
英文名称:
PCSK9
国产/进口:
国产
产地/品牌:
华安生物/HUABIO
型号:
鼠单克隆抗体
参考报价:
2500/100ul
总点击数:
2677
更新日期:
2019-12-09
产品类别:

性能参数
抗原介绍
Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC-1, is a 692 amino acid protein that belongs to the peptidase S8 family and contains one peptidase S8 domain. Important in the regulation of plasma cholesterol homeostasis, PCSK9 binds to low-density lipid receptor family members LDLR, very low-density lipid receptor (VLDLR) and apolipoprotein receptor 2 (ApoER2) and promotes their degradation in intracellular acidic compartments. PCSK9 also plays a role in neuronal differentiation and apoptosis. PCSK9 is expressed in Shwann cells, neuro-epithelioma, colon carcinoma, and hepatic and pancreatic cell lines. PCSK9 levels in the brain are highest in the cerebellum during perinatal development, with ischemia causing increased levels in the adult brain. Defects in the gene encoding this protein causes the autosomal dominant disorder familial hypercholesterolemia 3 (HCHOLA3).
Recommended Dilutions:
WB: 1:500-1:1,000              ICC: 1:50-1:200
HC: 1:50-1:200                   FC: 1:50-1:200
 
Fig1: Western blot analysis of PCSK9 on PANC-1 using anti-PCSK9 antibody at 1/100 dilution.
 
 
Fig2: Western blot analysis of PCSK9 on H22 (1) and SW1990 (2) using anti-PCSK9 antibody at 1/500 dilution.
 
 
Fig3: ICC staining PCSK9 (green) in LOVO cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
 
 
Fig4: ICC staining PCSK9 (green) in PANC-1 cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
 
 
Fig5: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-PCSK9 antibody. Counter stained with hematoxylin.
 
 
Fig6: Immunohistochemical analysis of paraffin-embedded human colon caner tissue using anti-PCSK9 antibody. Counter stained with hematoxylin.
 
 
Fig7: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-PCSK9 antibody. Counter stained with hematoxylin.
 
 
Fig8: Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-PCSK9 antibody. Counter stained with hematoxylin.
 
 
Fig9:Flow cytometric analysis of Hela cells with PCSK9 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated Goat anti mouse IgG was used as the secondary antibody.
公司简介

杭州华安生物技术有限公司成立于2007年3月,总部位于中国杭州,是一家从事抗体研发与生产的国家高新技术企业。公司致力于为全球的科研工作者和工业客户提供高品质的抗体试剂及抗体服务。
    公司的产品线包括兔单抗、小鼠单抗、兔多抗、二抗、蛋白/多肽、基因敲除细胞、抗体检测用相关试剂等。2015年,公司开始专注于高通量重组兔单克隆抗体的研发与产业化生产。
    同时,公司也为客户提供定制抗体开发、纯化和筛选服务迄今为止,公司累计完成超过 3000个定制抗体项目,涉及植物、动物、医学、水产、病毒等不同的科研领域。用户使用公司抗体在Science、Immunity、Nature Communications、Autophagy、Plant Cell、Cell Research等杂志上发表文章。
    公司不但专注于自身技术体系的完善和升级,还注重推动产学研合作:与浙江大学、四川大学、西南大学、中国科学院遗传与发育生物学研究所等知名院校共同承担省级和国家级课题,与杭州精准医药研究中心进行深度合作,进行技术成果交流和共享。

 

Hangzhou HuaAn Biotechnology Co., Ltd (HuaBio) was founded in 2007. Our headquarter is located in Hangzhou, China. With over 3,000 antibodies developed, HuaBio is committed to providing high-quality antibodies and antibody services to our customers. We have products including recombinant rabbit monoclonal antibodies, mouse monoclonal antibodies, rabbit polyclonal antibodies, phosphor-specific antibodies, secondary antibodies.

HuaBio is also committed to providing the highest quality in customized antibody services . By now, we have delivered more than 3000 customized antibodies for specific applications in various fields (e.g.Neuroscience, Epigenetics, Stem Cells, Microbiology, Signal Transduction Apoptosis and etc. )


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