FK-506 生化试剂现货7折促销啦~绝对最低价！
2013-08-13 来源:本站 点击次数:3546
产品名称：FK-506
化学名：Tacrolimus, fujimycin, Prograf, Advagraf, Protopic
CAS No： 104987-11-3
分子式：C44H69NO12
分子量：804.02
纯度：≥99%
溶解度：Soluble in DMSO or ethanol at 100 mg/mL; very poorly soluble in water;
保存：-20 ºC
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货号：abs810040
规格： 大包装询价
货号 产品名称 规格
abs810040a FK-506 5mg
abs810040b FK-506 10mg
abs810040c FK-506 25mg
abs810040d FK-506 50mg
abs810040e FK-506 100mg
库存：现货
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生物活性：
FK-506 is an immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the
activity of the patient's immune system and so lower the risk of organ rejection. It is also used in a topical
preparation in the treatment of atopic dermatitis (eczema), severe refractory uveitis after bone marrow
transplants, exacerbations of minimal change disease, and the skin condition vitiligo. It reduces
interleukin-2 (IL-2) production by T-cells.
FK-506 reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP12 (FK506 binding
protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin thus
inhibiting both T-lymphocyte signal transduction and IL-2 transcription.
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