2024年6月2日-6月6日,第72届美国质谱年会(ASMS)在美国阿纳海姆隆重举行!BSI携最新版本的PEAKS®系列软件与DeepImmu®免疫肽组发现服务、PEAKS AB®多克隆抗体测序服务新品亮相大会!
PEAKS® 新版本软件亮点
- 全面支持ThermoFisher Hybrid-DIA、AB SCIEX ZT Scan DIA数据的快速、准确分析;
- 支持Bruker TimsTOF ddaPASEF抗体测序数据分析。
- DeepNovo® Peptidome workflow算法升级,全面支持DDA和DIA数据的免疫肽组分析。
- 免疫肽组分析支持基因关联、序列变异和翻译后修饰位点鉴定。
- PEAKS DB search通过深度学习提升MS2评分,鉴定数量提升10%。
- DIA数据分析性能大幅提升,速度更快、更灵敏、更准确,更好的短梯度数据分析支持。
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会议期间,CTO辛磊博士受邀参加了深度学习从头测序算法的技术研讨会,在会上分享了PEAKS®算法团队在de novo sequencing领域多年的工作成果,以及deep learning技术当下的应用及对未来的展望。作为首个将深度学习应用到de novo sequencing的算法模型,BSI的DeepNovo®也得到后续众多算法的借鉴与引用。
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此外,对于近几年大热的免疫多肽研究,会场的相关墙报几乎也成了PEAKS®专场。来自Helmboltz Institute of Translational Oncology Mainz,Genentech,The Children's Hospital of Philadelphia,Baylor college of Medicine, Roche, ADA Forsyth Institute,Regeneron等临床机构、制药公司,学术单位展示了他们利用PEAKS的DeepNovo Peptidome或者de novo sequencing工作流在免疫多肽组发现中的数据分析应用。蒙特利尔大学的Pierre Thibault教授也在口头报告中分享了他们在非小细胞肺癌方面利用PEAKS进行的相关工作成果。
本次会议BSI及百蓁生物共展出6张墙报,涉及新抗原发现方法和流程,多抗测序方法,从头测序算法,数据统计等方面,引起了众多业内同行的兴趣并讨论。TP 566 An AI-driven, proteogenomics-based and complete workflow for novel neoantigen discovery
Authors: Qing Zhang [1], Kyle Hoffman [1], Sahar Rabinoviz [1], Peng Chao [2], Haibo Bian [1], Wenting Li [1], Lei Xin [1], Baozhen Shan [1]
[1] Bioinformatics Solutions Inc., Waterloo, ON
[2] Baizhen Biotechnology (Shanghai) Co., Ltd., Shanghai 201112, China
ThP 058 A Bayesian model for estimating the posterior error probability and the false discovery rate of de novo peptide sequencing
Authors: Hieu Tran [1], Rui Qiao [1], Lei Xin [1], Baozhen Shan [1]
[1] Bioinformatics Solutions Inc., Waterloo, ONWP 047 Revolutionizing Proteomics: Ultra-Fast, High-Accuracy Peptide Sequencing with Enhanced GraphNovo AlgorithmAuthors: Zeping Mao [1], Lei Xin[1], Shengying Pan [1], Baozhen Shan [1]
[1] Bioinformatics Solutions Inc., Waterloo, ON
WP 704 Combining Top-Down and Bottom-Up Mass Spectrometry Paves the Way for High Throughput Polyclonal Antibody Sequencing
Authors: Lei Xin [1], Peng Chao [2], Jun Ma [2], Shuyang Zhang [1], Zihao Wang [1], Wenting Li [1], Kyle Hoffman [1], Ailee Aihemaiti [1], Baozhen Shan [1]
[1] Bioinformatics Solutions Inc., Waterloo, ON
[2] Baizhen Biotechnology (Shanghai) Co., Ltd., Shanghai 201112, China
MP 451 Confident identification of proteome-wide low-level mutations using PEAKS 11.5
Authors: Kyle Hoffman [1], Julie Genereaux [2], Lei Xin [1], Zia Rahman [1], Christopher J Brandl [2], Patrick O’Donoghue [2], Baozhen Shan [1]
[1] Bioinformatics Solutions Inc., Waterloo, ON
[2] Western University, London, ON
TP 576 Distinguishing MIPs in the cell surface or in processing by MS with Immunoprecipitation and Mild Acid Elution methods
Authors: Chao Peng[1], Ping Wu[1], Haofei Miao[1], Ling Li[1], Baozhen Shan [2]
[1] BaizhenBio (Wuhan) Inc., Hubei, China
[2] Bioinformatics Solutions Inc., Waterloo, ON
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作为生物信息学的领军企业,BSI专注于蛋白质组学和生物药领域,通过机器学习和先进算法提供世界领先的质谱数据分析软件和蛋白质组学服务解决方案,以推进生物学研究和药物发现。我们通过基于AI的计算方案,为您提供对蛋白质组学、基因组学和医学的卓越洞见。旗下著名的PEAKS®️系列软件在全世界拥有数千家学术和工业用户,包括:PEAKS®️ Studio,PEAKS®️ Online,PEAKS®️ GlycanFinder, PEAKS®️ AB,DeepImmu®️免疫肽组发现服务和抗体综合表征服务等。
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