目前，全球及中国糖尿病肥胖等代谢疾病的发病率越来越高，越来越需要我们认真去研究对待，因此对糖尿病肥胖等代谢疾病的研究越来越多。

     该研究一般以大小鼠为实验对象，通过大小鼠的呼吸商（即呼入氧气和呼出二氧化碳的比值）来对大小鼠的能量消耗进行评估，除此之外可能需要给大小鼠提供喂食饮水，并对喂食饮水进行量和次数的监测，也需要对其尿液进行收集，也需要同时监测活动情况，体重 心率等功能的监测。

       国内外现在对糖尿病和肥胖营养等疾病研究越来越深入：以下是一些相关的文章做参考：

客户名称	作者	发表文章	收录杂志
南京大学模式动物中心	高翔	Interaction of MAGED1 with nuclear receptors affects circadian clock function	EMBO Journal
中科院营养所	郭非凡	Leucine Deprivation Decreases Fat Mass by Stimulation of Lipolysis in White Adipose Tissue and Upregulation of Uncoupling Protein 1 (UCP1) in Brown Adipose Tissue	Diabetes
		ATF4 regulates lipid metabolism and thermogenesis	CELL RESEARCH
中科院营养所	刘勇	Abrogation of Hepatic ATP-Citrate Lyase Protects Against Fatty Liver and Ameliorates Hyperglycemia in Leptin Receptor-Deficient Mice	HEPATOLOGY
		Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis	PNAS美国科学院院刊
		Signaling through Tyr985 of Leptin Receptor as an Age/Diet-Dependent Switch in the Regulation of Energy Balance	MOLECULAR AND CELLULAR BIOLOGY

A high-fat, ketogenic diet induces a unique metabolic state in mice

Adam R. Kennedy,¹ Pavlos Pissios,¹ Hasan Otu,² Bingzhong Xue,¹ Kenji Asakura,¹ Noburu Furukawa,¹ Frank E. Marino,¹ Fen-Fen Liu,¹ Barbara B. Kahn,¹ Towia A. Libermann,² and Eleftheria Maratos-Flier¹Am J Physiol Endocrinol Metab 292: E1724-E1739, 2007

Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice

Alexander V. Mayorov^a,b, Neri Amara^c, Jason Y. Chang^a,b, Jason A. Moss^a,b Mark S. Hixon^a,b, Diana I. Ruiz^a,b, Michael M. Meijler^c,1, Eric P. Zorrilla^d,e,1, and Kim D. Janda^a,b,f,g,1
PNAS November 11, 2008 vol. 105 no. 45 17487-17492

A Novel Method for High Throughput Phenotyping of Sleep in Mice

Allan I Pack¹*, Raymond J. Galante², Greg Maislin¹, Jacqueline Cater², Dimitris Metaxas³, Shan Lu³, Lin Zhang², Randy Von Smith⁴, Timothy Kay², Jie Lian², Karen Svenson⁴, and Luanne L Peters⁵Physiol. Genomics (September 19, 2006). doi:10.1152/physiolgenomics.00139.2006

Reduced sensitivity to diet-induced obesity in mice carrying a mutant 5-HT6 receptor

Andrea Frassetto^a, Jiaping Zhang^a, Julie Z. Lao^a, Amanda White^b, Joseph M. Metzger^b, Tung M. Fong^a and Richard Z. Chen^a

Brain Research Volume 1236, 21 October 2008, Pages 140-144

Hemodynamic effects of substance P and its receptor antagonist RP67580 in anesthetized rats with carbon tetrachloride-induced cirrhosis

Andres Cardenas ^ab; Robert Lowe ^c; Sangik Oh ^a; Sheila Bodkin ^c; Tom Kenney ^c; Wayne W. Lamorte ^d; Nezam H. Afdhal ^a
Scandinavian Journal of Gastroenterology, Volume 43, Issue 3 2008 , pages 328 - 333

更多文章请参考