人横纹肌肉瘤细胞株A-204
T细胞株
成纤维细胞株
小鼠Mo-MuLv感染的3T3细胞株
推荐培养基:（FM, Cat. No. 2301）

储存：液氮

运输：干冰

用途：科研

The most abundant cell type in lung interstitium is

fibroblasts. They resemble ordinary fibroblasts but have

some distinguishing features, for example, they have long

branching processes ａnd gap junctions. Their principle

function is production of type III collagen, elastin, ａnd

proteoglycans of the extracellular matrix of the alveolar

septa. Pulmonary fibroblasts （PF） play an important role

in the repair ａnd remodeling processes following injury.

The controlled accumulation of fibroblasts to sites of

inflammation is crucial to effective tissue repair after

injury [1]. Either inadequate or excessive accumulation of

fibroblasts could result in abnormal tissue function. For

example, the excess proliferation of fibroblasts

contributes to the adventitial thickening observed during

the development of hypoxia-induced pulmonary hypertension

[2].

HPF from ScienCell Research Laboratories are isolated from

human lung tissue. HPF are cryopreserved at primary culture

ａnd delivered frozen. Each vial contains >5 x 105 cells in

1 ml volume. HPF are characterized by immunofluorescent

method with antibody to fibronectin. HPF are negative for

HIV-1, HBV, HCV, mycoplasma, bacteria, yeast ａnd fungi.

HPF are guaranteed to further expand for 15 population

doublings at the conditions provided by ScienCell Research

Laboratories.

Reference
[1] Kuwano K, Hagimoto N, Hara N. （2001） Molecular

mechanisms of pulmonary fibrosis ａnd current treatment.

Curr Mol Med 1（5）:551-73.
[2] Das M, Dempsey EC, Reeves JT, Stenmark KR. （2004）

Selective expansion of fibroblast subpopulations from

pulmonary artery adventitia in response to hypoxia. Am J

Physiol Lung Cell Mol Physiol 282（5）:L976-86