血蓝蛋白

英文名：Keyhole limpet hemocyanin

英文简称：KLH

中文别名：血蓝素

来源：美洲鲎血淋巴（Limulus polyphemus hemolymph）

货号：K8160

规格：10mg /100mg

分子量：8000-9000kDa

CAS：9013-72-3

纯度：Protein ≥85 % by biuret

应用：生物活性测定、免疫学研究、封闭血蓝蛋白抗体

北京索莱宝科技有限公司，主要做生化试剂耗材。
联系人：陈天添 手机：13439225985
QQ:609810384

血蓝蛋白来源：美洲鲎血淋巴（Limulus polyphemus hemolymph）
血蓝蛋白纯度：Protein ≥85 % （by biuret）
血蓝蛋白已知杂质：0.10-0.20%
血蓝蛋白保存：冻干粉 2-8°C 至少 2 年。配制后的溶液–20 °C 可保存 2 个月，在含有 0.1%叠氮钠的条件下 2-8°C 保存，请 2 周内使用完。 

血蓝蛋白应用：血蓝蛋白是在某些软体动物、节肢动物(蜘蛛和甲壳虫)的血淋巴中发现的一种游离的蓝 色呼吸色素。血蓝蛋白含两个直接连接多肽链的铜离子，与含铁的血红蛋白类似，它易于氧结合， 也易与氧解离，是已知的惟一可与氧可逆结合的铜蛋白，氧化时呈青绿色，还原时呈白色。节肢动 物中血蓝蛋白的含量比软体动物的含量要高。具有载氧功能、抗病毒活性、抗菌活性、凝血功能。 其应用广泛，可以用于生物活性测定、免疫学研究、封闭血蓝蛋白抗体。

研究背景：

KLH is used extensively as a carrier protein in the production of antibodies for research, biotechnology and therapeutic applications. Haptens are substances with a low molecular weight such as peptides, small proteins and drug molecules that are generally not immunogenic and require the aid of a carrier protein to stimulate a response from the immune system in the form of antibody production. KLH is the most widely employed carrier protein for this purpose. KLH is an effective carrier protein for several reasons. Its large size and numerous epitopes generate a substantial immune response, and abundance of lysine residues for coupling haptens allows a high hapten:carrier protein ratio, increasing the likelihood of generating hapten-specific antibodies. In addition, because KLH is derived from the limpet, a gastropod, it is phylogenetically distant from mammalian proteins, thus reducing false positives in immunologically-based research techniques in mammalian model organisms.KLH can also be a challenging molecule to work with because of its propensity to aggregate and precipitate. Aggregates remain immunogenic, but limit the ability to conjugate haptens, and are difficult to manipulate in the laboratory. A high-quality KLH preparation with clear opalescent blue color is the best indicator of KLH solubility.

北京索莱宝科技有限公司，主要做生化试剂耗材。
联系人：陈天添 手机：13439225985
QQ:609810384

运输和储存：4℃运输，-20℃储存，避免反复冻融。