MK 677 - Ibutamoren mesylate L-163194
159752-10-0 (salt)
C28H40N4O8S2 MW 624.77
Purity: 99% (optically pure)
Soluble in water to 100 mM
Biological Activity:
Potent and orally active growth hormone (GH) secretagogue.
References: online 1, 2, 3, 4, 5
T Jacks et al. MK-0677, a potent, novel, orally active growth hormone (GH) secretagogue: GH, insulin-like growth factor I, and other hormonal responses in beagles. Endocrinology, 1996, 137, 5284-5289.
MG Murphy et al. MK-677, an Orally Active Growth Hormone Secretagogue, Reverses Diet-Induced Catabolism. J. Clin. Endocrinol. Meta. 1998, 83, (2), 320-325.
LA Sorbera et al. Ibutamoren Mesylate. Drugs Fut. 2006, 31(5), 390.
E Codner et al. Effects of oral administration of ibutamoren mesylate, a nonpeptide growth hormone secretagogue, on the growth hormone–insulin-like growth factor I axis in growth hormone–deficient children. Clin. Pharmacol. Ther. 2001, 70, 91–98.
Chemical Name: 2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxo-3-(phenylmethoxy)propan-2-yl]propanamide methanesulfonic acid
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