Temsirolimus - CCI-779 - Torisel
C56H87NO16 MW 1030.29
Purity: 99%
Soluble in DMSO
Biological Activity:
Specific mTOR inhibitor; a signaling protein that regulates cell growth and angiogenesis; a therapeutic for the treatment of advanced renal cell carcinoma (RCC), kidney cancer and other cancer types.
References: online 1 2
X Wan et al. CCI-779 Inhibits rhabdomyosarcoma xenograft growth by an antiangiogenic mechanism linked to the targeting of mTOR/HIF-1alpha/VEGF signaling. Neoplasia 2006, 8(5), 394–401. [online]
D DelBufalo et al. Antiangiogenic potential of the mammalian target of rapamycin inhibitor temsirolimus. Cancer Res. 2006, 66(11), 5549–5554. [online]
GV Thomas et al. Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. Nature Medicine 2006, 12(1), 122–127. [online]
Chemical Name:
Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.
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