MS 245 oxalate
263384-65-2 (parent)
C19H22N2O3S.C2H2O4 MW 448.49
Purity: 99%
Soluble in DMSO to 34 mM
Biological Activity:
Selective and high affinity 5-HT6 antagonist (Ki = 2.1 nM).
References: online
Y Tsai et al. N1-(Benzenesulfonyl)tryptamines as novel 5-HT6 antagonists.
Bioorg Med Chem Lett. 2000, 10(20), 2295-2299. [online]
R Young et al. Effect of the 5-HT(6) serotonin antagonist MS-245 on the actions of (-)nicotine. Pharmacol. Biochem. Behav. 2006, 85(1), 170-1777. [online]
M Dukat et al. Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies. J. Med. Chem. 2008, 51, 603. [online]
RVS Nirogi et al. Novel and potent 5-piperazinyl methyl-N1-aryl sulfonyl indole derivatives as 5-HT6 receptor ligands. ACS Med. Chem. Lett. 2010, 1, 340. [online]
Chemical Name: 2-(5-methoxy-1-(phenylsulfonyl)-1H-indol-3-yl)-N,N-dimethylethanamine oxalate
MS 245 oxalate | 5-HT6 antagonist | Axon Medchem | Axon 1849 | MS245
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