药物筛选系统 FDSS7000EX--性能参数，报价/价格，图片

基本信息

产品名称：

药物筛选系统 FDSS7000EX

英文名称：

国产/进口：

进口

产地/品牌：

日本滨松

型号：

FDSS7000EX

参考报价：

询价

销售商：

滨松光子学商贸（中国）有限公司

总点击数：

12240

更新日期：

2026-04-02

产品类别：

药检/制药仪器

性能参数

产品介绍
FDSS7000EX是我们公司的高端型号，能处理1536-孔的荧光和发光现象的分析和测量，还配置有洗涤等多种功能。多种悬浮/贴壁细胞的实时动力学反应能被测量和分析。多种可选部件，包括FRET，机器人连接等可供选择。另外，FDSS7000EX还能实现未来的升级扩展。
FDSS7000EX 药物筛选系统详细参数

型号	FDSS7000EX
主单元尺寸	约 1500 mm (W)×1030 mm (D)×1450 mm (H)
主单元	约 300 kg
数据分析系统尺寸	600 mm (W)×700 mm (D)×1500 mm (H)
数据分析系统重量	约 50 kg
泵浦单元尺寸	500 mm (W)×500 mm (D)×1200 mm (H)
泵浦单元重量	约 50 kg

产品介绍

● 细胞内钙离子
● 膜电位
● 离子通道
● 水母发光
● FRET
● 悬浮细胞
◇ 测量实例：细胞内钙离子

硬件

适配器
可配备各种分配头

● 可选择96-，384-或1536-尖端的分配头。型号是可以交换的。

● 支持384和1536针脚头。

● 主机配备自动尖端加载功能。

● 标准情况下，可以分配三种类型的化合物。如果使用背板加载线，最多可以分配四种类型的化合物。
● 用户可以容易地更换分配头。

清洗单元

配备各种洗涤功能

● 最多支持三种溶剂，无需携带即可进行清洗。

● 在测量过程中可以提示清洗。

● 提供超声清洗功能。

● 配备擦拭阶段以干燥尖端。

板堆积单元
板堆积功能适用于20或50个板

● 使用平板堆叠器，即使不使用机器人也可以进行自动测量。

● 您可以选择20个板或50个板。

● 堆叠器盒式方法可以轻松设置印版。

● 可配备条形码阅读器。

板震动功能
板振动提供稳定的响应检测。

● 可以在对整个板施加精细振动的同时进行测量。
● 细胞和试剂可以有效且快速地混合。
● 这对于使用悬浮细胞的测定也是有效的

荧光/发光传感器、荧光光学
板振动提供稳定的响应检测。使用单个传感器支持荧光测定和发光测定

● 该传感器的荧光检测灵敏度远远超过传统荧光传感器。
● 因为可以降低激发光，所以可以降低购买激发光源的成本。
● 除了高灵敏度，FDSS7000EX还具有高动态范围。
● 荧光变换器使FRET测量成为可能。
使用氙灯和滤光片组合（多次激发和发射）的各种分析
● 通过落射照明光学系统实现良好的波长分离
● Fura-2测定双激发（340 nm和380 nm）
● 具有发射滤光片更换器的FRET（C / Y，膜电位）
● 2个二向色镜和4个发射滤光片槽，用于各种分析
● 带有瓦数选项的白光氙灯（150 W，300 W，600 W）
● 6个过滤槽用于激励
● 均匀的板照明

FDSS Application Note No.2 Comparison of No Wash Reagent Kits on the FDSS6000 [0.4MB/PDF]

FDSS Application Note No.3 Effect of Plate Mixing, Fluid Addition Height and Speed on Reducing Addition Artifacts and Negative Control Drift Using the FDSS6000 [0.1MB/PDF]

FDSS Application Note No.4 Comparison of Orthogonal Technologies to Confirm Agonist Hits Generated Using the FDSS6000 [0.1MB/PDF]

FDSS Application Note No.5 Detection and Modulation of Cardiomyocyte Calcium Oscillations Using the FDSS6000 [0.1MB/PDF]

FDSS Application Note No.6 Fluorescence Quenching in Cell-Based Assays Can Be Dye Specific: A Case Study Using Both Fura-2 AM and Fluo-4 AM Calcium Reporter Dyes Using the FDSS6000 [0.1MB/PDF]

FDSS Application Note No.7 Incorporating Cell Viability Assays into High Throughput Screening Using the FDSS6000 [0.1MB/PDF]

FDSS Application Note No.8 Evaluation of a new intracellular calcium fluorescent reagent using the FDSS6000 [0.3MB/PDF]

FDSS Application Note No.9 Exposing cells to a single pulse of light of user-defined wavelength and duration using the FDSS6000 [0.1MB/PDF]

FDSS Application Note No.10 FluxORTM Differentially Identifies K+ Channel Antagonists Using FDSS6000 [0.1MB/PDF]

FDSS Application Note No.11 Use of Ca2+ oscillations in primary neuron culture: a new HTS model for neuronal diseases [0.2MB/PDF]

FDSS Application Note No.12 β-arrestin recruitment for GPCR Screening [0.1MB/PDF]

FDSS Application Note No.13 Fast kinetics enzyme assay High-throughput screening of prolyl isomerase (Pin1) inhibitors [0.2MB/PDF]

FDSS Application Note No.14 New Tools for Drug Discovery: Multiplexing the monitoring of Ca2+ and cAMP signaling in primary cells using the FDSS/μCell. [0.2MB/PDF]

FDSS Application Note No.15 Cell-based fluorescent assay for selectivity evaluation between two Na+ channels subtypes [0.2MB/PDF]

FDSS Option 1: 1536-Well Format Option with Disposable Tips and Pin Tool Head [0.2MB/PDF]

FDSS Option 2: High Speed Acquisition Option [0.2MB/PDF]

附加信息

FDSS Application Note No.22 High Speed Acquisition for FDSS series [0.5MB/PDF]

出版文献

通过PubMed和基于网络的资源查看完整的引文时请选择一个标题。

2011

Ferain T, Hoveyda H, Ooms F, Schols D, Bernard J, Fraser G. Agonist-Induced Internalization of CC Chemokine Receptor 5 as a Mechanism to Inhibit HIV Replication J Pharmacol Exp Ther. 2011 Jun;337(3):655-62.
Yasuaki Sanada, Tsunekazu Mizushima, Yasuyuki Kai, Junichi Nishimura, Hiroshi Hagiya, Haruto Kurata, Hirotaka Mizuno, Etsuko Uejima, Toshinori Ito Therapeutic Effects of Novel Sphingosine-1-Phosphate Receptor Agonist W-061 in Murine DSS Colitis. PLoS ONE 6(9): e23933. doi:10.1371/journal.pone.0023933
Pantel J, Williams SY, Mi D, Sebag J, Corbin JD, Weaver CD, Cone RD. Development of a high throughput screen for allosteric modulators of melanocortin-4 receptor signaling using a real time cAMP assay Eur J Pharmacol. 2011 Jun 11;660(1):139-47. Epub 2011 Feb 4
David Weaver, C. Triple-Addition Assay Protocols for Detecting and Characterizing Modulators of Seven-Transmembrane Receptors. Current Protocols in Chemical Biology. 119-140
Meredith J Noetzel, Jerri M Rook, Paige N Vinson, Hyekyung Cho, Emily Days, Y Zhou, Alice L Rodriguez, Hilde Lavreysen, Shaun R Stauffer, Colleen M Niswender, Zixiu Xiang, J Scott Daniels, Crag W Lindsley, C David Weaver and P Jeffrey Conn Functional Impact of Allosteric Agonist Activity of Selective Positive Allosteric Modulators of mGlu5 in Regulating CNS Function. Molecular Pharmacology October 21, 2011,mol.111.075184

2010

Ke Liu, Noel Southall, Steve A. Titus, James Inglese, Robert L. Eskay, Paul Shinn, Christopher P. Austin, Markus A. Heilig and Wei ZhengA Multiplex Calcium Assay for Identification of GPCR Agonists and Antagonists. Assay Drug Dev Technol. 2010 Jun;8(3):367-79
Brad P. Barnett, Yousang Hwang, Martin S. Taylor, Henriette Kirchner, Paul T. Pfluger, Vincent Bernard, Yu-yi Lin, Erin M. Bowers, Chandrani Mukherjee, Woo-Jin Song, Patti A. Longo, Daniel J. Leahy, Mehboob A. Hussain, Matthias H. Tschop, Jef D. Boeke and Philip A. Cole Glucose and Weight Control in Mice with a Designed Ghrelin O-Acyltransferase Inhibitor. Science 17 December 2010: Vol. 330 no. 6011 pp. 1689-1692
Shuzo Watanabe, Masashi Ohmi, Tadashi Inoue, Chizu Nonomura, Akiyoshi Fujiuchi Identification of novel TRPM8 channel antagonists, Poster by RaQualia Pharma Inc.
Evan P Lebois, Thomas M Bridges, L. Michelle Lewis, Eric S Dawson, Alexander S. Kane, Zixiu Xiang, Satyawan B Jadhav, Huiyong Yin, J. Phillip Kennedy, Jens Meiler, Colleen M. Niswender, Carrie K Jones, P Jeffrey Conn, C David Weaver, and Craig W Lindsley Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M1 receptor function in the central nervous system. ACS Chem Neurosci. 2010; 1(2): 104-121

2009

Titus SA, Beacham D, Shahane SA, Southall N, Xia M, Huang R, Hooten E, Zhao Y, Shou L, Austin CP, Zheng W. A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel. Anal Biochem. 2009 Nov 1;394(1):30-8. Epub 2009 Jul 5
Zhou Y, Rodriguez AL, Williams R, Weaver CD, Conn PJ, Lindsley CW.Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTS. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6502-6. Epub 2009 Oct 28.
Felts AS, Saleh SA, Le U, Rodriguez AL, Weaver CD, Conn PJ, Lindsley CW, Emmitte KA. Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. Epub 2009 Oct 9.
Williams R, Niswender CM, Luo Q, Le U, Conn PJ, Lindsley CW. Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-lead. Bioorg Med Chem Lett. 2009 Feb 1;19(3):962-6. Epub 2008 Dec 25.
Rodriguez AL, Williams R, Zhou Y, Lindsley SR, Le U, Grier MD, Weaver CD, Conn PJ, Lindsley CW. Discovery and SAR of novel mGluR5 non-competitive antagonists not based on an MPEP chemotype .Bioorg Med Chem Lett. 2009 Jun 15;19(12):3209-13. Epub 2009 May 3.
Williams R, Johnson KA, Gentry PR, Niswender CM, Weaver CD, Conn PJ, Lindsley CW, Hopkins CR. Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4). Bioorg Med Chem Lett. 2009 Sep 1;19(17):4967-70. Epub 2009 Jul 18.
Kim Y, Kang S, Lee JY, Rhim H. High throughput screening assay of alpha(1G) T-type Ca2+ channels and comparison with patch-clamp studies .Comb Chem High Throughput Screen. 2009 Mar;12(3):296-302.
Weaver CD, Sheffler DJ, Lewis LM, Bridges TM, Williams R, Nalywajko NT, Kennedy JP, Mulder MM, Jadhav S, Aldrich LA, Jones CK, Marlo JE, Niswender CM, Mock MM, Zheng F, Conn PJ, Lindsley CW. Discovery and development of a potent and highly selective small molecule muscarinic acetylcholine receptor subtype I (mAChR 1 or M1) antagonist in vitro and in vivo probe. Curr Top Med Chem. 2009;9(13):1217-26.
Mori T, Itami S, Yanagi T, Tatara Y, Takamiya M, Uchida T. Use of a Real-Time Fluorescence Monitoring System for High-Throughput Screening for Prolyl Isomerase Inhibitors. J Biomol Screen. 2009 Apr;14(4):419-24.
Wise H, Abel PW, Cawkill D. Use of Reduced Temperature Cell Pausing to Enhance Flexibility of Cell-Based Assays. J Biomol Screen. 2009 Jul;14(6):716-22. Epub 2009 May 21.
Sharma S, Kedrowski J, Rook JM, Smith RL, Jones CK, Rodriguez AL, Conn PJ, Lindsley CW. Discovery of molecular switches that modulate modes of metabotropic glutamate receptor subtype 5 (mGlu5) pharmacology in vitro and in vivo within a series of functionalized, regioisomeric 2- and 5-(phenylethynyl)pyrimidines. J Med Chem. 2009 Jul 23;52(14):4103-6.
Engers DW, Niswender CM, Weaver CD, Jadhav S, Menon UN, Zamorano R, Conn PJ, Lindsley CW, Hopkins CR. Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs). J Med Chem. 2009 Jul 23;52(14):4115-8.
Bridges TM, Marlo JE, Niswender CM, Jones CK, Jadhav SB, Gentry PR, Plumley HC, Weaver CD, Conn PJ, Lindsley CW. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J Med Chem. 2009 Jun 11;52(11):3445-8.
Shirey JK, Brady AE, Jones PJ, Davis AA, Bridges TM, Kennedy JP, Jadhav SB, Menon UN, Xiang Z, Watson ML, Christian EP, Doherty JJ, Quirk MC, Snyder DH, Lah JJ, Levey AI, Nicolle MM, Lindsley CW, Conn PJ. A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning. J Neurosci. 2009 Nov 11;29(45):14271-86.
Sheffler DJ, Williams R, Bridges TM, Xiang Z, Kane AS, Byun NE, Jadhav S, Mock MM, Zheng F, Lewis LM, Jones CK, Niswender CM, Weaver CD, Lindsley CW, Conn PJ. A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning. Mol Pharmacol. 2009 Aug;76(2):356-68. Epub 2009 Apr 30.
Marlo JE, Niswender CM, Days EL, Bridges TM, Xiang Y, Rodriguez AL, Shirey JK, Brady AE, Nalywajko T, Luo Q, Austin CA, Williams MB, Kim K, Williams R, Orton D, Brown HA, Lindsley CW, Weaver CD, Conn PJ. Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity. Mol Pharmacol. 2009 Mar;75(3):577-88. Epub 2008 Dec 1.
Lewis LM, Bhave G, Chauder BA, Banerjee S, Lornsen KA, Redha R, Fallen K, Lindsley CW, Weaver CD, Denton JS. High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1. Mol Pharmacol. 2009 Nov;76(5):1094-103. Epub 2009 Aug 25.
Irukayama-Tomobe Y, Tanaka H, Yokomizo T, Hashidate-Yoshida T, Yanagisawa M, Sakurai T. Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3930-4. Epub 2009 Feb 23.
Delpire E, Days E, Lewis LM, Mi D, Kim K, Lindsley CW, Weaver CD.Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5383-8. Epub 2009 Mar 11.

2008

Lewis LM, Sheffler D, Williams R, Bridges TM, Kennedy JP, Brogan JT, Mulder MJ, Williams L, Nalywajko NT, Niswender CM, Weaver CD, Conn PJ, Lindsley CW. Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonists. Bioorg Med Chem Lett. 2008 Feb 1;18(3):885-90. Epub 2008 Jan 4.
Niswender CM, Lebois EP, Luo Q, Kim K, Muchalski H, Yin H, Conn PJ, Lindsley CW. Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators.Bioorg Med Chem Lett. 2008 Oct 15;18(20):5626-30. Epub 2008 Aug 29.
Kim HJ, Yun HM, Kim T, Nam G, Roh EJ, Kostenis E, Choo HY, Pae AN, Rhim H. Functional human 5-HT6 receptor assay for high throughput screening of chemical ligands and binding proteins. Comb Chem High Throughput Screen. 2008 May;11(4):316-24.
Gunnet JW, Wines P, Xiang M, Rybczynski P, Andrade-Gordon P, de Garavilla L, Parry TJ, Cheung WM, Minor L, Demarest KT, Maryanoff BE, Damiano BP. Pharmacological characterization of RWJ-676070, a dual vasopressin V(1A)/V(2) receptor antagonist. Eur J Pharmacol. 2008 Aug 20;590(1-3):333-42. Epub 2008 Jun 7.
Akasofu S, Sawada K, Kosasa T, Hihara H, Ogura H, Akaike A. Donepezil attenuates excitotoxic damage induced by membrane depolarization of cortical neurons exposed to veratridine. Eur J Pharmacol. 2008 Jul 7;588(2-3):189-97. Epub 2008 Apr 13.
Jones CK, Brady AE, Davis AA, Xiang Z, Bubser M, Tantawy MN, Kane AS, Bridges TM, Kennedy JP, Bradley SR, Peterson TE, Ansari MS, Baldwin RM, Kessler RM, Deutch AY, Lah JJ, Levey AI, Lindsley CW, Conn PJ. Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats. J Neurosci. 2008 Oct 8;28(41):10422-33.
Kobayashi K, Nishizawa Y, Sawada K, Ogura H, Miyabe M. K(+)-channel openers suppress epileptiform activities induced by 4-aminopyridine in cultured rat hippocampal neurons. Pharmacol Sci. 2008 Dec;108(4):517-28. Epub 2008 Dec 11.
Niswender CM, Johnson KA, Luo Q, Ayala JE, Kim C, Conn PJ, Weaver CD. A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the pharmacology of the group III metabotropic glutamate receptors. Pharmacol. 2008 Apr;73(4):1213-24. Epub 2008 Jan 2.
Niswender CM, Johnson KA, Weaver CD, Jones CK, Xiang Z, Luo Q, Rodriguez AL, Marlo JE, de Paulis T, Thompson AD, Days EL, Nalywajko T, Austin CA, Williams MB, Ayala JE, Williams R, Lindsley CW, Conn PJ. Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Mol Pharmacol. 2008 Nov;74(5):1345-58. Epub 2008 Jul 29.
Shirey JK, Xiang Z, Orton D, Brady AE, Johnson KA, Williams R, Ayala JE, Rodriguez AL, Wess J, Weaver D, Niswender CM, Conn PJ.An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. Nat Chem Biol. 2008 Jan;4(1):42-50. Epub 2007 Dec 2.
Ayala JE, Niswender CM, Luo Q, Banko JL, Conn PJ. Group III mGluR regulation of synaptic transmission at the SC-CA1 synapse is developmentally regulated Neuropharmacology. 2008 Apr;54(5):804-14. Epub 2007 Dec 24.
Taniguchi Y, Tonai-Kachi H, Shinjo K. 5-Nitro-2-(3-phenylpropylamino)benzoic acid is a GPR35 agonist Pharmacology. 2008;82(4):245-9. Epub 2008 Sep 26.

2007

Park JH, Choi JK, Lee E, Lee JK, Rhim H, Seo SH, Kim Y, Doddareddy MR, Pae AN, Kang J, Roh EJ. Lead discovery and optimization of T-type calcium channel blockers Bioorg Med Chem. 2007 Feb 1;15(3):1409-19. Epub 2006 Nov 10.
Yun HM, Kim S, Kim HJ, Kostenis E, Kim JI, Seong JY, Baik JH, Rhim H. The novel cellular mechanism of human 5-HT6 receptor through an interaction with Fyn . J Biol Chem. 2007 Feb 23;282(8):5496-505. Epub 2006 Dec 22.
Cassutt KJ, Orsini MJ, Abousleiman M, Colone D, Tang W. Identifying Nonselective Hits from a Homogeneous Calcium Assay Screen J Biomol Screen. 2007 Mar;12(2):285-7. Epub 2007 Feb 8.
Song F, Lu S, Gunnet J, Xu JZ, Wines P, Proost J, Liang Y, Baumann C, Lenhard J, Murray WV, Demarest KT, Kuo GH. Synthesis and biological evaluation of 3-aryl-3-(4-phenoxy)-propionic acid as a novel series of G protein-coupled receptor 40 agonists J Med Chem. 2007 Jun 14;50(12):2807-17. Epub 2007 May 15.
Hemstapat K, Da Costa H, Nong Y, Brady AE, Luo Q, Niswender CM, Tamagnan GD, Conn PJ. A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors J Pharmacol Exp Ther. 2007 Jul;322(1):254-64. Epub 2007 Apr 6.
McNamara CR, Mandel-Brehm J, Bautista DM, Siemens J, Deranian KL, Zhao M, Hayward NJ, Chong JA, Julius D, Moran MM, Fanger CM.TRPA1 mediates formalin-induced pain Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13525-30. Epub 2007 Aug 8.

2006

2005

2004

2003

Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation

2002

2001

公司简介

成立于1953年的日本滨松光子学株式会社（以下简称滨松集团），是世界上科技水平最高、市场占有率最大的光科学、光产业公司。使用滨松集团11200支20英寸光电倍增管的东京大学小柴昌俊教授的中微子实验获得2002年的诺贝尔物理学奖。滨松集团的产品被广泛的应用在医疗生物、高能物理、宇宙探测、精密分析等产业领域，是光产业界的领军企业。为了更好的贡献于中国光产业，紧跟中国十二五规划的步伐，在2011年10月成立“滨松光子学商贸（中国）有限公司”。

滨松集团的中国业务最早可追溯到1988年，当时接到中国方面的技术支援请求后，与北京核仪器厂共同投资兴建了北京滨松光子技术有限公司（以下简称北京滨松），现在作为光电倍增管等的生产销售基地在中国国内创下了每年约1.3亿元（约16.5亿日元：以下按1元等于13日元换算）的销售业绩。另一方面，通过本集团直接贸易实现的销售额高达约2.3亿元（约30亿日元），中国国内需求有不断扩大的趋势。在这一背景下，近几年很多欧美顾客都在中国成立生产基地，而最近随着中国国内需求的扩大，他们又开始在中国成立产品开发基地，由此无形中也带动了中国企业的成长。

因此，随着中国十二五规划的要求，中国相关研究所和企业加快了高新技术研究的步伐，在宇宙探测、新能源开发、重离子治疗、正电子CT（PET）等方面要求我们提供更加优质和便捷的服务。所以在中国加大销售、技术支持和产品售后服务等相关市场活动也逐渐显现出其必要性，为此我们在中国成立了滨松光子学商贸（中国）有限公司（简称滨松中国）。将来，还预计根据当地的需求设立相应的开发体制，以更好的服务于中国。

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