100%原装正品现货cst 2135s CD2AP抗体
CST 2135S CD2AP Antibody100μl
CD2AP Antibody #2135
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| REACTIVITY | SENSITIVITY | MW (kDa) | SOURCE |
|---|---|---|---|
| H M R Mk | Endogenous | 80 | Rabbit |
Western blot analysis of extracts of K562, A431 and COS cells, using CD2AP Antibody.
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Product Usage Information
| Application | Dilutions |
| Western Blotting | 1:1000 |
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity / Sensitivity
CD2AP Antibody detects endogenous levels of total CD2AP protein.
Species Reactivity: Human, Mouse, Rat, Monkey
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to amino acids near the carboxy terminus of human CD2AP. Antibodies are purified by protein A and peptide affinity chromatography.
Background
CD2AP is a scaffolding protein that is thought to link membrane proteins to the cytoskeleton (1-3). It plays a role in formation of tight junctions in specialized cell types such as the slit diaphragm in the kidney glomerulus (4). CD2AP is also involved in the immunological synapse between CD2 expressing T cells and antigen presenting cells (5). It has been shown that interaction between CD2AP and other cytoskeletal proteins may regulate the endocytosis of EGFR (3).
1. Kirsch, K.H. et al. (1999) Proc Natl Acad Sci U S A 96, 6211-6.
2. Kirsch, K.H. et al. (2001) J Biol Chem 276, 4957-63.
3. Lynch, D.K. et al. (2003) J Biol Chem 278, 21805-13.
4. Kawachi, H. et al. (2006) Nephrology (Carlton) 11, 274-81.
5. Hutchings, N.J. et al. (2003) J Biol Chem 278, 22396-403.
Entrez-Gene Id 23607
Swiss-Prot Acc. Q9Y5K6
Data Sheets & Documentation
Data sheet (99KB)
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