G蛋白偶联受体ARHGEF18抗体
产品编号 | bs-7144R |
英文名称 | ARHGEF18 |
中文名称 | G蛋白偶联受体ARHGEF18抗体 |
别 名 | p114RhoGEF; 114 kDa Rho specific guanine nucleotide exchange factor; ARHGEF 18; ARHGEF18; KIAA0521; MGC15913; p114 Rho GEF; p114-Rho-GEF; Rho specific guanine nucleotide exchange factor p114; Rho-specific guanine nucleotide exchange factor p114; Rho/Rac guanine nucleotide exchange factor (GEF) 18; Rho/Rac guanine nucleotide exchange factor 18; SA RhoGEF; Septin associated RhoGEF; ARHGI_HUMAN. |
规格价格 | 0.1ml/800元 购买 0.2ml/1280元 购买 |
说 明 书 | 0.1ml 0.2ml |
研究领域 | 细胞生物 信号转导 G蛋白偶联受体 G蛋白信号 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep, |
产品应用 | WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 131kDa |
细胞定位 | 细胞浆 |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/1ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human ARHGEF18 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
生 产 商 | BIOSS |
PubMed | PubMed |
产品介绍 | background: Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]. Function: Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). p114RgoGEF cts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. It may play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS), but does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Subunit: Interacts with SEPT9; interaction may inhibit GEF activity. Interacts with Gbetagamma subunits GNB1 and GNG2. Subcellular Location: Cytoplasm. Note: Colocalizes with actin stress fibers. Tissue Specificity: Expressed in all tissues tested with highest expression in kidney and pancreas. Weakly or not expressed in liver, skeletal muscle and testis. Similarity: Contains 1 DH (DBL-homology) domain. Contains 1 PH domain. Database links: Entrez Gene: 23370 Human Entrez Gene: 102098 Mouse SwissProt: Q6ZSZ5 Human SwissProt: Q6P9R4 Mouse Unigene: 465761 Human Unigene: 736818 Human Unigene: 170461 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
北京博奥森生物技术有限公司成立于2001年,注册资本2000万元,是集免疫学科研试剂研发、生产、销售为一体的国家高新技术企业。在公司近1300平米的研发中心楼内,拥有SPF级实验动物房、GMP级单克隆抗体制备平台,同时购置了CSBio多肽合成仪、Akta全自动液相色谱系统、BD流式细胞仪、Leica冷冻切片机等多种生产、检测仪器。公司还拥有一批技术精湛、经验丰富的科研开发团队,在免疫和分子生物学等领域拥有多项自主知识产权。
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