alpha 1肾上腺素能受体A抗体--性能参数，报价/价格，图片

基本信息

产品名称：

alpha 1肾上腺素能受体A抗体

英文名称：

ADRA1A

国产/进口：

国产

产地/品牌：

bioss

型号：

bs-0600R

参考报价：

销售商：

北京博奥森生物技术有限公司

总点击数：

469

更新日期：

2017-05-03

产品类别：

抗体

性能参数

产品编号	bs-0600R
英文名称	ADRA1A
中文名称	alpha 1肾上腺素能受体A抗体
别名	ADA1A_HUMAN; Adrenergic alpha 1A receptor; Adrenergic alpha 1C receptor; Adrenergic alpha 1D receptor; alpha 1 Adrenergic Receptor; Alpha 1A adrenergic receptor; Alpha-1A adrenergic receptor; Alpha-1A adrenoreceptor; Alpha-1C adrenergic receptor; Alpha-adrenergic receptor 1c; ADRA1A; ADRA1C; Alpha 1A adrenoceptor; alpha-1A adrenergic receptor isoform 1; adrenergic, alpha-1A-, receptor variant 1; adrenergic, alpha-1A-, receptor variant 3; adrenergic, alpha-1A-, receptor variant 5; adrenergic, alpha-1A-, receptor variant 8; G protein coupled receptor; alpha-1A adrenoceptor; ADRA1L1; ALPHA1AAR.
规格价格	0.1ml/580元购买 0.2ml/960元购买
说明书	0.1ml 0.2ml
研究领域	细胞生物神经生物学细胞膜受体
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig,
产品应用	WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-300 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	51kDa
细胞定位	细胞核细胞膜
性状	Lyophilized or Liquid
浓度	1mg/1ml
免疫原	KLH conjugated synthetic peptide derived from human Alpha-1A
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
生产商	BIOSS
PubMed	PubMed
产品介绍	background: Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]. Function: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. Subunit: Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes. Subcellular Location: Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes. Tissue Specificity: Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart. Post-translational modifications: C-terminal Ser or Thr residues may be phosphorylated. Similarity: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily. Gene ID: 148 Database links: Entrez Gene: 148 Human Entrez Gene: 11549 Mouse Entrez Gene: 29412 Rat Omim: 104221 Human SwissProt: P35348 Human SwissProt: P97718 Mouse SwissProt: P43140 Rat Unigene: 52931 Human Unigene: 709175 Human Unigene: 57064 Mouse Unigene: 9991 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. ADRA1肾上腺素能α1受体位于突触后，在血管平滑肌上，兴奋时可使血管收缩; alpha 1-adrenergic receptor有兴奋效应也有抑制效应。肾上腺素能受体又可分为α和β两种。alpha 受体与儿茶酚胺结合后，主要是兴奋平滑肌，如血管收缩、子宫收缩和瞳孔开张肌收缩等；但也有抑制作用，如使小肠平滑肌舒张。β受体又可分为β1和β2两个亚型.

公司简介

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