Lumazone 系列是美国Princeton Instruments（Roper Technologies, Inc. 集团子公司）研制的活体生物发光成像系统，可以观察并成像将生物发光标记后的植物整体标本，并结合专业的分析软件完成植物体内基因表达的原位跟踪、植物突变体监测和筛选以及单细胞内的基因表达等研究。
    Roper 公司一直致力于将其最佳性能的光学成像系统推荐给客户，并凭借在生命科学研究领域多年来积累的经验，能够根据客户需求为客户量身定制成像系统，已成为在此领域中具领先地位的系统供应商之一。
    为了满足植物学研究的需要，解决植物活体荧光成像时叶绿体荧光干扰的问题，博益公司推出了多款专业型的植物整体分子影像系统，包括最新的 Lumazone SOPHIA 2048B、Lumazone PyLoN1300B 和 Lumazone PyLoN2048B 等，并针对不同的实验需求配置突变体筛选暗箱或光周期暗箱。实验无需将植物样本做任何处理，并可通过生物发光(LUC)和荧光方法实时观察植物样本基因表达的变化，准确定量分析。

Lumazone SOPHIA 2048B特点：
    Princeton Instruments 公司最新研发的 Lumazone SOPHIA 植物活体成像系统，实现了电子制冷 CCD的超低暗电流：SOPHIA 是目前唯一的使用风冷方式就能达到-90℃制冷温度的相机。SOPHIA 的信噪比非常高，适合长时间曝光的发光成像。同时，其芯片尺寸 30.7mm × 30.7mm，使得单个像素的尺寸达到 15.0μm × 15.0μm，单个像素的感光面积增大，更适合植物活体的弱光成像。

» 2048×2048 分辨率
» 风冷/水冷-90℃
» 15μm 像素(灵敏度提升23%)
» 最快读出速度16MHz(3.2fps)
» 读出噪声低，成像质量高
» 全金属、密封设计；终身保证真空，操作时无需维护
常见应用：高通量，非低表达筛选、突变体筛选，逆境处理研究，生物节律，激素信号，蛋白质互作

植物学部分参考文献：

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2. A Pre-mRNA-Splicing Factor Is Required for RNA-Directed DNA Methylation in  Arabidopsis. PLoS Genet (2013) 9(9): e1003779
3. Aequorin-Based Luminescence Imaging Reveals Stimulus- and Tissue-Specific Ca2+ Dynamics in Arabidopsis Plants. Molecular Plant (2013) 6(2): 444-455
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7. Ultra-weak photon emission as a non-invasive tool for the measurement of oxidative stress induced by UVA radiation inArabidopsis thaliana. Journal of Photochemistry and Photobiology B (2013) 123: 59-64
8. A histone acetyltransferase regulates active  DNA demethylation in Arabidopsis. Science (2012) 336:1445-1448
9. A DNA 3’-phosphatase functions in  active DNA demethylation in Arabidopsis. Mol Cell (2012) 45(3): 357-370
10. Antisilencing role of the RNA-directed DNA methylation  pathway and a histone acetyltransferase in Arabidopsis. Proc. Natl. Acad. Sci. (2012) 109: 11425-11430
11. A Plasma Membrane Receptor Kinase, GHR1, Mediates ABA- and H2O2-regulated Stomatal Movement in Arabidopsis. Plant Cell (2012) 24: 2546-2561
12. Development of a luciferase-based reporter of transcriptional  gene silencing that enables bidirectional mutant screening in Arabidopsis. Silence (2012) 3(1):6
13. The Arabidopsis AP2/ERF Transcription Factor RAP2.11 Modulates PlantResponse to Low-Potassium Conditions. Mol Plant, Mar (2012) 10: 1093/mp/sss003
14. LIGHT-REGULATED WD1 and PSEUDO-RESPONSE REGULATOR9 Form a Positive Feedback Regulatory Loop in the Arabidopsis Circadian Clock. The Plant Cell (2011) 23: 486-498
15. The Plant Cuticle Is Required for Osmotic Stress Regulation of Abscisic Acid Biosynthesis and Osmotic Stress Tolerance in Arabidopsis. The Plant Cell (2011) 23: 1971-1984
16. A Peroxidase Contributes to ROS Production during Arabidopsis Root Response to Potassium Deficiency. Molecular Plant (2010) 3：420-427
17. Ethylene Mediates Response and Tolerance to Potassium Deprivation in Arabidopsis. The Plant Cell (2009) 21: 607-621
18. NRPD4, a protein related to the RPB4 subunit of RNA polymerase II, is a component of RNA polymerases IV and V and is required for RNA-directed DNA methylation. Genes & Development   (2009) 23:318-330
19. A conserved transcriptional regulator is required for RNA-directed DNA methylation and plant development. Genes & Development (2009) 23: 2717-2722
20. Disruption of Arabidopsis CHY1 Reveals an Important Role of Metabolic Status in Plant Cold Stress Signaling. Molecular Plant (2009) 2:59-72
21. Isolation and Characterization of cul1-7, a Recessive Allele of CULLIN1 That Disrupts SCF Function at the C Terminus of CUL1 in Arabidopsis thaliana. Genetics (2009)181: 945-963
22. COP1-Mediated Ubiquitination of CONSTANS Is Implicated in Cryptochrome Regulation of Flowering in Arabidopsis. The Plant Cell (2008) 20: 292-306

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