The four tocopherols (α, β, δ, and γ) and four tocotrienols (α, β, δ, and γ) are forms of vitamin E, which is known for its antioxidant activity.¹ Tocotrienols are found at high concentrations in palm oil and rice bran. Recent studies show tocotrienols may be more effective antioxidants than α-tocopherol, the most abundant form of vitamin E.² Compared to other tocotrienols, α-tocotrienol exhibits the most potent neuroprotective actions in rat striatal neurons. At concentrations of 0.1-10 µM, α-tocotrienol significantly suppresses H₂O₂-induced cell death and provides protection against S-nitrocysteine-induced cell death and SIN-1 toxicity in a concentration dependent manner.² HT4 cells, that are microinjected with 10⁻¹⁹ mol of α-tocotrienol into the cytosolic, are protected against glutamate-induced cell death by suppressing early activation of c-Src kinase and 12-lipoxygenase.³

1 Kamal-Eldin, A., and Appelqvist, L. The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids 31 671-701 (1996).

2 Osakada, F., Hashino, A., Kume, T., et al. α-Tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons. Neuropharmacology 47 904-915(2004).

3 Khanna, S., Roy, S., Slivka, S., et al. Neuroprotective properties of the natural vitamin E α-tocotrienol. Stroke 36 2258-2264(2005).

其它相关产品：

三烯生育酚α-Tocotrienol
生育三烯酚β-Tocotrienol​
三烯生育酚γ-Tocotrienol
三烯生育酚δ-Tocotrienol

生素E系列产品如下：
Vitamin E: Tocopherols & Tocotrienols

生育酚
Contents: 
d-α-tocopherol, 98.5+% [CAS 59-02-9] 1 vial x 250 mg
d-β-tocopherol, 98.5+% [CAS 148-03-8] 1 vial x 250 mg
d-γ-tocopherol, 98.5+% [CAS 54-28-4] 1 vial x 250 mg
d-δ-tocopherol, 98.5+% [CAS 119-13-1] 1 vial x 250 mg
2,2,5,7,8-Pentamethyl-6-hydroxychroman (PMC), 99.0+% [CAS 950-99-2] 1 vial x 250 mg
Note: PMC is used as the internal standard for HPLC analysis of tocopherol, but not for GC analysis.
Storage condition: 
Each vial is aluminum-packed with an oxygen adsorbent. One opening the vials, store the reagent under inert gas in a refrigerator in the dark. Under such conditions, the reagents are stable for 6 months.
Instruction for use (Preparation of each solution)
Weigh 50 ~ 100 mg of each reagent by chemical balance, to the nearest 0.1mg.
Add ethanol or hexane to dissolve the reagent to the final concentration of 1 mg vitamin homologue/mL as the stock solution. The stock solution in tightly capped vials are stable at 5 degrees C for a month.
The standard solutions for each homologue can be prepared by dilution the stock solution just before use.

1072                     rac-α-Tocopherol 50 mg  95+% TLC/98+% GC
1071                     rac-β-Tocopherol 50 mg  95+% TLC/98+% GC
1073                     rac-γ-Tocopherol  50 mg  95+% TLC/98+% GC
1790                     δ-Tocopherol        50 mg   95+% TLC/98+% GC
1074           rac-5,7-Dimethyltocol    50 mg  95+% TLC/98+% GC
1797                      Tocol                      50 mg  95+% TLC/98+% GC
α β γ δ -   三烯生育酚 标准品 
Research use only. Do not administer it to human.
2109          α-Tocotrienol    25 mg  98+% TLC/98+% GC
2110          β-Tocotrienol    25 mg  98+% TLC/98+% GC
2111          γ- Tocotrienol    25 mg  98+% TLC/98+% GC
2112          δ-Tocotrienol    25 mg  98+% TLC/98+% GC

References:
1. Ahn, K., et al. (2007) J Biol Chem. 282:809-820
2. Kannappan, R., et al. (2010) J Biol Chem. 285:33520
3. Tan, B., (2005) The Journal of the American Neutricutical Association 8(1):35
4. Kannappan, R., et al. (2012) Genes Nutr. 7:43-52
5. Mangialasche, F., et al. (2012) Neurobiol. Aging 33(10):2282-2290
6. Patel, V., et al. (2011) Indian J Exp Biol. 49(10):732-738
7. Vasanthi, HR., et al. (2011) Curr Pharm Des. 17(21):2170-2175

     Vitamin E consists of four tocopherols and four tocotrienols that demonstrate important and far reaching biological activities.  These essential lipids contain a common chromanol ring and either a saturated (tocopherol) or unsaturated (tocotrienol) side chain.  The eight common vitamin E isoforms (α-, β-, γ-, and δ-tocopherols and α-, β-, γ-, and δ-tocotrienols) are differentiated based on the number and position of methyl groups on the chromanol ring and the presence of a saturated or unsaturated side chain (figure 1 (pg. 2)).  The vitamin E vitamers are commonly found in vegetables, fruits, seeds, nuts, grains and oils, where they exist in various ratios with each other.  The unsaturated side chain in tocotrienols gives them physical properties different from tocopherols, such as an increased ability to cross the cell membrane bilayer (1).  Vitamin E has become well known for its role as an antioxidant, in lowering cholesterol and other lipids, as a neuroprotective and anti-cancer agent, and in cardiovascular disease protection.  Most vitamin E supplements contain (and many studies use) only α-tocopherol; however, several of the above biological effects are mostly or exclusively found in the other vitamers, making it critical for them to be included in future research.  Indeed, the tocotrienols in general may have greater physiological functions than tocopherols (2) and may even be inhibited by an unbalanced excess of α-tocopherol supplements (3).
    Scientists at the MD Anderson Cancer Center wrote an excellent article entitled “Tocotrienols fight cancer by targeting multiple cell signaling pathways” (4).  Here it is suggested that since tumor cells result from dysregulation of multiple genes a drug is needed that will also target multiple genes.  Tocotrienols affect numerous pathways linked with tumorigenesis and thus have potential in both the prevention and treatment of cancer as an active and mild anti-cancer drug.
     A recent report from the Karolinska Institute in Sweden described the neuroprotective activity of tocopherols and tocotrienols (5).  It is indicated that low plasma tocopherol and tocotrienol levels are associated with an increased incidence of mild cognitive impairment and Alzheimer’s disease.  Another report indicates that α-tocotrienol is the most potent neuroprotective form of vitamin E, inhibiting 12-LOX, c-Src, and PLA2, up-regulating MRP1, and inducing arteriogenesis through induction of TIMP1 and decreased activation of MMP2 (6).

     Another beneficial function of tocopherols and tocotrienols is their role in preventing cardiovascular disease.  The tocotrienols particularly have gained eminence recently due to an increased understanding of their antioxidant effects.  Cardioprotective effects of tocotrienols include antagonizing the oxidation of low density lipoproteins, anti-atherosclerotic properties, inhibiting platelet aggregation and monocytes adhesion, and preventing smooth muscle proliferation (7).
    Since its discovery, vitamin E has been shown to be a versatile and potent component of biological systems.  α-Tocopherol has received much praise over the years due to its remarkable functions; now the less prevalent tocopherols and tocotrienols are starting to gain recognition as indispensable components of the vitamin E family.  As Kannappan et al. point out more than 25,000 studies have been conducted on tocopherol while very few studies have considered the role of tocotrienols (4).  
But this is sure to change as more scientists become aware that “The multitargeted role of tocotrienols in most degenerative diseases proves it to be an ideal candidate as a nutraceutical/pharmaceutical agent for useful exploitation” (7).  Matreya is pleased to introduce the full line of highly purified Tocopherols and Tocotrienols along with Tocols as internal standard markers.  We have the capability to produce these compounds in multigram sizes to accommodate your research.
          
母育酚

dl-Tocol         250mg    97+ % 
用途：生体内等のビタミンEの定量に使用される内標準物質「トコール」です    30306921
其它维生素 系列产品 Vitamin
水溶性维生素          
烟酸    Nicotinic acid    C 15521000/250mg
盐酸吡哆醛（B6）    Pyridoxal hydrochloride    /
二盐酸吡哆胺（B6）    Pyridoxamine dihydrchloride    /
抗坏血酸钠    Sodium ascorbate    C 10303900/250mg
盐酸硫胺（B1）    Vitamin B1 hydrochloride    C 17455000/250mg
硝酸硫胺（B1）    Vitamin B1 mononitrate    C 17455500/250mg
核黄素（B2）    Vitamin B2    C 16813600/250mg
烟酰胺（B3/B5）    Nicotinamide    C 15519500/250mg
泛酸钙（B3/B5）    Calcium pantothenate    CA15845000/250mg
泛酸钠    D-Pantothenic acid sodium salt    C 15845100/250mg
吡哆素（B6）    Vitamin B6    /
盐酸吡哆素（B6）    Vitamin B6 hydrochloride    C 16652000/250mg
氰钴胺素（B12）    Vitamin B12    CA11798500/50mg
对氨苯甲酸Bx    Vitamin Bx    C 10171400/100mg
抗坏血酸（C）    Vitamin C    C 10303000/250mg
抗坏血酸钙（C）    Calcium ascorbate    C 10303100/250mg
异抗坏血酸    D(-)-Isoascorbic acid    C 14379000/250mg
生物素（H）    Vitamin H    C 10625000/250mg
叶酸    Folic acid    C 13888000/250mg
           
脂溶性维生素          
视黄醇    Retinol    R7632-100mg
维生素A酸    Tretinoin    C 17608000/250mg
维生素A乙酸酯    Retinol acetate    CA17923820/150mg
维生素A棕榈酸酯    Retinol palmitate    CA17923840/150mg
胆钙化甾醇（D3）    Cholecalciferol    CA17924000/150mg
DL-a-生育酚（E）    DL-a-Tocopherol    CA17924300/500mg
DL-a-生育酚乙酯    DL-a-Tocopherylacetate    CA17924320/500mg
维生素K1    Phytonadione    C 17924400/250mg
甲萘醌（K3）    Menadione    C 14863000/250mg
b-胡萝卜素    b-Carotene    CA11045800/250mg
虾青素    Astaxanthin    CA10307000/250mg
角黄素    Canthaxanthin    CA10947000/150mg
硫辛酸    DL-6,8-Thioctic acid    /
麦角钙化甾醇（D2）    Ergocalciferol    CA17923900/150mg
a-琥珀酸（E）    a-Tocopheryl acid succinate    /
叶黄素    Lutein    CA14652000/50mg

维生素E相关产品:

订货号	中文名称	英文名称	CAS#	规格	价格
VIT-001N	盐酸硫胺/维生素B1	Vitamin B1 hydrochloride	[67-03-8]	1g	询价
VIT-002N	核黄素/维生素B2	Vitamin B2	[83-88-5]	1g	询价
C16813600	维生素B2	(-)-Riboflavin (Vitamin B2)	[83-88-5]	0.25g	330
VIT-005N	烟酸/维生素B3	Nicotinic Acid	[59-67-6]	1g	询价
C15519500	烟酰胺/维生素PP	Nicotinamide	[98-92-0]	0.25g	330
VIT-006N	烟酰胺	Nicotinamide	[98-92-0]	1g	询价
VIT-003N	盐酸吡哆辛/维生素B6	Vitamin B6	[58-56-0]	1g	询价
C13888000	叶酸/维生素Bc	Folic acid	[59-30-3]	0.25g	330
VIT-007N	叶酸 (维生素M)	Vitamin M	[59-30-3]	1g	询价
C10625000	维生素B7/维生素H/D-生物素	D (+)-Biotin	[58-85-5]	0.25g	360
VIT-009N-R1	D-生物素/维生素H	Vitamin H	[58-85-5]	100mg	询价
CA11798500	维生素B12/腈钴胺	Vitamin B12	[68-19-9]	50mg	330
VIT-010N-R1	腈钴胺 (维生素B12)	Vitamin B12	[68-19-9]	25mg	询价
C16880000	维生素P/ 芦丁水合物	Rutin hydrate	[153-18-4]	0.5g	300
VIT-004N	L-抗坏血酸/维生素C	Vitamin C	[50-81-7]	1g	询价
C10303000	L-抗坏血酸/维生素C	L- (+)-Ascorbic acid	[50-81-7]	0.25g	300
VIT-008N	泛酸	D-Pantothenic acid	[137-08-6]	100mg	询价
CA11045800	β-胡萝卜素	beta-Carotene	[7235-40-7]	0.25g	450
CA17923820	维生素A乙酸酯	Vitamin A acetate	[127-47-9]	0.15g	870
VIT-014N	维生素A棕榈酸酯	Vitamin A palmitate	[79-81-2]	100mg	询价
CA17923840	维生素A棕榈酸酯	Vitamin A palmitate	[79-81-2]	0.15g	870
CA17924300	DL-α-维生素E	DL-alpha-Tocopherol	[10191-41-0]	0.5g	405
CA17924320	DL-α-维生素E乙酸酯	DL-alpha-Tocopherylacetate	[7695-91-2]	0.5g	450
CA17923900	维生素D2	Vitamin D2	[50-14-6]	0.1g	405
C13201500	麦角固醇 (维生素D2原)	Ergosterol (Provitamin D2)	[57-87-4]	0.1g	360
CA17924000	胆钙化固醇/维生素D3	Vitamin D3	[67-97-0]	0.15g	450
VIT-013N	胆钙化固醇 (维生素D3)	Vitamin D3	[67-97-0]	100mg	询价
CA17924100	25-羟基-维生素D3一水合物	Vitamin D3 25-hydroxy monohydrate	[63283-36-3]	50mg	945
C17924400	维生素K1	Vitamin K1	[84-80-0]	0.25g	450
VIT-017N	甲萘醌/维生素K2	Vitamin K2	[11032-49-8]	100mg	询价
C14863000	维生素K3	Menadione (Vitamin K3)	[58-27-5]	0.25g	405
011-16641	抗坏血酸标准品	L (+)-Ascorbic Acid Standard	[7488-99-5]	10mg	2,810
035-17981	α-胡萝卜素标准品	α-Carotene Standard	[7235-40-7]	10mg	900
032-17991	β-胡萝卜素标准品	β-Carotene Standard	[79-81-2]	20capsules	560
188-01331	维生素A棕榈酸酯标准溶液	Retinol Palmitate Standard Solution	[83-88-5]	200mg	560
182 -01611	维生素B2标准品	Riboflavin Standard	[58-56-0]	200mg	560
168-20031	吡哆醇盐酸盐标准品	Pyridoxine Hydrochloride Standard	[65-22-5]	200mg	560
165-20041	吡哆醇盐酸盐标准品	Pyridoxal Hydrochloride Standard	[524-36-7]	200mg	1,120
162-20051	盐酸吡多胺标准品	Pyridoxamine DiHydrochloride Standard	[50-81-7]	200mg	400
011-16641	维生素C标准品	L (+)-Ascorbic Acid Standard	[84-80-0]	200mg	2,240
167-19011	维生素K1标准品	Phylloquinone Standard	[27750-10-3]	200mg	790
084-07821	(-)-羟基柠檬酸钙标准品	(-)-Hydroxycitric Acid Calcium Salt Standard	[2124-57-4]	20mg	3,030
133-14331	甲萘醌-7标准品／维生素K2 (35)	Menaquinone-7 Standard	[863-61-6]	100mg	2,470
136-16641	甲萘醌-4标准品／维生素K2 (20)	Menaquinone-4 Standard		1 set	4,900

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