山莨菪碱 Anisodamine 55869-99-3上海惠诚
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| Cat. Number |
A5334
|
| Chemical Name |
山莨菪碱 Anisodamine
|
| CAS Number |
55869-99-3
|
| Mol. Formula |
C17H23NO4
|
| Mol. Weight |
305.37
|
| Qty 1 |
100mg
|
| Qty 2 |
500mg
|
| Appearance |
White crystalline powder
|
| Application Notes |
≥98%
|
| Synonym |
6-Hydroxy hyoscyamine,α-(hydroxymethyl)benzeneacetic acid-6-hydroxy- 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester
|
| Melting Pt. |
103-113°C
|
| Storage condition |
Ambient
|
| References |
Anisodamine is a tropane alkaloid originally found in plants in the Solanaceae family; it exhibits anti-inflammatory activity and is clinically used to induce atropinization in organophosphate poisoning subjects and to improve acute lung injury pathology and respiratory parameters. Anisodamine inhibits α1-adrenergic receptors and muscarinic acetylcholine receptors (mAChRs). Anisodamine is also clinically used to treat acute glomerulonephritis and diabetic nephropathy, and also to improve renal microcirculation. Additionally, anisodamine decreases expression of VEGF and ICAM-1 and suppresses inflammatory cell infiltration and proliferation, decreasing perivascular hemorrhage in animal models of phlebitis. 参考文献： Wang W, Chen QF, Li QB, et al. Efficiency of anisodamine for organophosphorus-poisoned patients when atropinization cannot be achieved with high doses of atropine. Environ Toxicol Pharmacol. 2014 Mar;37(2):477-81. PMID: 24561530. Guoshou Z, Chengye Z, Zhihui L, et al. Effects of high dose of anisodamine on the respiratory function of patients with traumatic acute lung injury. Cell Biochem Biophys. 2013 Jun;66(2):365-9. PMID: 23504631. Geng W, Fu XH, Gu XS, et al. Preventive effects of anisodamine against contrast-induced nephropathy in type 2 diabetics with renal insufficiency undergoing coronary angiography or angioplasty. Chin Med J (Engl). 2012 Oct;125(19):3368-72. PMID: 23044290. Zhang ZX, Wang P, Zhang QS, et al. Effects of anisodamine on the expressions of vascular endothelial growth factor and intercellular adhesion molecule 1 in experimental infusion phlebitis. Chin Med J (Engl). 2012 Jan;125(2):300-5. PMID: 22340563. Zhang WW, Song MK, Cui YY, et al. Differential neuropsychopharmacological influences of naturally occurring tropane alkaloids anisodamine versus scopolamine. Neurosci Lett. 2008 Oct 10;443(3):241-5. PMID: 18672024. Varma DR, Yue TL. Adrenoceptor blocking properties of atropine-like agents anisodamine and anisodine on brain and cardiovascular tissues of rats. Br J Pharmacol. 1986 Mar;87(3):587-94. PMID: 2879586. |
上海惠诚生物科技有限公司，成立于2010年，企业宗旨“惠质产品，挚诚服务”。惠诚生物自成立以来，一直致力于为客户提供一站式科学服务，产品覆盖设计开发全过程，提供实验室设计、实验室建设、仪器设备、耗材、试剂、技术服务等专项配套服务。上海惠诚生物按照客户的研发、生产和质量控制环节整合各种优质资源，优化资源组合，为客户提供整体解决方案。
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“不忘初心，砥砺前行”。 上海惠诚生物经过多年不懈努力，目前产品线包括：生命科学，分析化学，生化试剂和仪器耗材。客户遍布：生物医药，体外诊断，食品行业，石油化工，科研院校和研究所等领域。
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