特别提示：包括重组人TNF-α(C端His标签)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人TNF-α(C端His标签)
英文名称：Recombinant Human Tumor Necrosis Factor alpha
产品货号：JN0467
产品规格：10μg|50μg|500μg|1mg

本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Val77-Leu233在C端含有His标签。

TNF-alpha质量控制：＞95%(还原性SDS-PAGE)

TNF-alpha制剂：冻干品

TNF-alpha保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

TNF-alpha复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于TNF-alpha：
Tumor Necrosis Factor-α (TNF-α) is secreted by macrophages, monocytes, neutrophils, T-cells, and NK-cells following stimulation by bacterial LPS. Cells expressing CD4 secrete TNF-α while cells that express CD8 secrete little or no TNF-α. Synthesis of TNF-α can be induced by many different stimuli including interferons, IL2, and GM-CSF. The clinical use of the potent anti-tumor activity of TNF-α has been limited by the proinflammatory side effects such as fever, dose-limiting hypotension, hepatotoxicity, intravascular thrombosis, and hemorrhage. Designing clinically applicable TNF-α mutants with low systemic toxicity has been of intense pharmacological interest. Human TNF-α that binds to murine TNF-R55 but not murine TNF-R7, exhibits retained anti-tumor activity and reduced systemic toxicity in mice compared with murine TNF-α, which binds to both murine TNF receptors. Based on these results, many TNF-α mutants that selectively bind to TNF-R55 have been designed. These mutants displayed cytotoxic activities on tumor cell lines in vitro and have exhibited lower systemic toxicity in vivo. Recombinant Human TNF-α High Active Mutant differs from the wild-type by amino acid subsitution of amino acids 1-7 with Arg8, Lys9, Arg10 and Phe157. This mutant form has been shown to have increased activity with less inflammatory side effects in vivo.


根据您的关注的重组人TNF-α(C端His标签)，重组人Tumor Necrosis Factor alpha，Recombinant Human Tumor Necrosis Factor alpha，重组TNF-α，重组Tumor Necrosis Factor alpha，rTNF-α，rhTNF-α，重组人TNF-α，您可能还对以下产品有需求：



名称：重组人NT3(神经营养素3)(含前导肽)
货号：JN0223
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备，目的基因编码的Asn19-Thr257表达纯化而来。

NT-3(with pro peptide)质量控制：＞95%(还原性SDS-PAGE)。

NT-3(with pro peptide)制剂：冻干品

NT-3(with pro peptide)保存：
冻干蛋白可在-20℃长期保存，室温也可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天。
复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。

NT-3(with pro peptide)复溶：
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存，避免反复冻融。

关于NT-3(with pro peptide)：
Pro-Neurotrophin-3 (pro-NT3) is the precursor form of Neurotrophin-3. Pro-NT3 interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature NT3 selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner.

关注重组人TNF-α(C端His标签)，重组人Tumor Necrosis Factor alpha，Recombinant Human Tumor Necrosis Factor alpha，重组TNF-α，重组Tumor Necrosis Factor alpha，rTNF-α，rhTNF-α，重组人TNF-α的同时，为您推荐更多您可能感兴趣的产品：


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