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产品名称：重组大鼠IL-33
英文名称：Recombinant Rat Interleukin 33
产品货号：GS4577
产品规格：2μg

分子量：Approximately 17.4kDa,a single non-glycosylated polypeptide chain containing 156 amino acids.
储存条件：冷冻（-20℃）

概述

Interleukin-33(IL-33),also known as NF-HEV and DVS 27,is a cytokine belonging to the IL-1 superfamily.It is also a proinflammatory protein that may regulate gene transcription and it induces helper T cells,mast cells,eosinophils and basophils to produce type 2 cytokines.The induction of type 2 cytokines by IL-33 in vivo is believed to induce the severe pathological changes observed in mucosal organs following administration of IL-33.IL-33 is constitutively expressed in smooth muscle and airway epithelia and it binds to a high-affinity receptor family member ST2.In vivo administration of mature IL-33 promotes increased production of IL-5,IL-13,IgE,and IgA,as well as splenomegaly and inflammatory infiltration of mucosal tissues.Recombinant rat IL-3 contains 156 amino acid residues and it shares 59%a.a.and 90%sequence identity with human and murine IL-33.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞95%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 0.5ng/ml,corresponding to a specific activity of>2.0×106 IU/mg.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in 20mMTris,300 mM NaCl,pH 8.5.
内毒素	Less than 1 EU/μg of rRtIL-33 as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	SIQGTSLLTE SCALSTYNDQ SVSFVLENGC YVINVEDCGK NQEKDKVLLR YYESSFPAQS GDGVDGKKLM VNMSPIKDTD IWLNANDKDY SVELQKGDVS PPDQAFFVLH KKSSDFVSFE CKNLPGTYIG VKDNQLALVE ENDESCNNIM FKLSKM

根据您的关注的重组大鼠IL-33，IL-33, Rat，重组Interleukin 33，Recombinant Rat Interleukin 33，重组大鼠Interleukin 33，您可能还对以下产品有需求：



名称：重组人VEGF-A(血管内皮生长因子)(VEGF164)
货号：JN0252
规格：10μg|50μg|500μg|1mg
本品由我们的酵母表达系统制备，目的基因编码的Ala27-Arg190表达纯化而来。

VEGF164质量控制：＞95%(还原性SDS-PAGE)。

VEGF164制剂：冻干品

VEGF164保存：
冻干蛋白可在-20℃长期保存，室温也可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天。
复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。

VEGF164复溶：
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存，避免反复冻融。

关于VEGF164：
Mouse Vascular endothelial growth factor (VEGF or VEGF­A), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the PDGF/VEGF growth factor family that is characterized by a cystine knot structure formed by eight conserved cysteine residues. Alternately spliced isoforms of 120, 164 and 188 aa found in mouse. VEGF binds the type I transmembrane receptor tyrosine kinases VEGF R1 (also called Flt­1) and VEGF R2 (Flk­/KDR) on endothelial cells.Although affinity is highest for binding to VEGF R1, VEGF R2 appears to be the primary mediator of VEGF angiogenic activity. VEGF is required during embryogenesis to regulate the proliferation, migration, and survival of endothelial cells.It may play a role in increasing vascular permeability during lactation, when increased transport of molecules from the blood is required for efficient milk protein synthesis.

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