兔抗γ1促黑素细胞激素(γ1-MSH)抗体
特别提示:包括兔抗γ1促黑素细胞激素(γ1-MSH)抗体在内,本公司的所有产品仅可用于科研实验,严禁用于临床医疗及其他非科研用途!
About this Antibody | |
Name | FGFR2/CD332 Mouse Monoclonal Antibody |
Category | Monoclonal antibody(mAb); Primary antibody |
Isotype | IgG1 |
Purification | ProA affinity purified |
About the Immunogen | |
Immunogen | This antibody is produced by immunizing mice with a recombinant protein corresponding to a region of FGFR2. |
Gene ID | 2263 |
SwissProt | P21802 |
Synonyms | bacteria-expressed kinase; BEK; BEK fibroblast growth factor receptor; BFR-1; CD332; CEK3; CFD1; ECT1; FGF receptor; FGFR-2; FGFR2; Fibroblast growth factor receptor 2; FLJ98662; hydroxyaryl-protein kinase; JWS; K-sam; Keratinocyte growth factor receptor |
Category | RTK |
Background | Fibroblast growth factor receptor 2 (FGFR2) also known as CD332 has two naturally occurring isoforms FGFR2IIIb and FGFR2IIIc, created by splicing of the third immunoglobulin-like domain. FGFR2IIIb is predominantly found in ectoderm derived tissues and endothelial organ lining, i.e. skin and internal organs. FGFR2 has important roles in embryonic development and tissue repair, especially bone and blood vessels. Like the other members of the Fibroblast growth factor receptor family, these receptors signal by binding to their ligand and dimerisation (pairing of receptors), which causes the tyrosine kinase domains to initiate a cascade of intracellular signals. As mentioned, FGFR2 mutations are associated with craniosynostosis syndromes, which are skull malformations caused by premature fusion of cranial sutures and other disease features according to the mutation itself. |
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