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产品名称:重组人超氧化物歧化酶1(SOD1)
英文名称:Recombinant Human Superoxide Dismutase [Cu-Zn]
产品货号:JN0864
产品规格:10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成,目的基因编码的Met1-Gln154在N端含有His标签。
SOD1质量控制:>95%(还原性SDS-PAGE)
SOD1制剂:液体
SOD1保存:收到货后请置于-20℃,可保存6个月,避免反复冻融。
关于SOD1:
Superoxide Dismutase [Cu-Zn] (SOD1) is a soluble cytoplasmic and mitochondrial intermembrane space protein that belongs to the Cu-Zn superoxide dismutase family. SOD1 binds copper and zinc ions and is one of three isozymes responsible for destroying free superoxide radicals in the body. SOD1 neutralizes supercharged oxygen molecules, which can damage cells if their levels are not controlled. The enzyme protects the cell against dangerous levels of superoxide. Zinc binding promotes dimerization and stabilizes the native form. Mutations in SOD1 cause a form of familial amyotrophic lateral sclerosis. Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1) which is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis.
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