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产品名称：重组人IL-21
英文名称：Recombinant Human Interleukin-21
产品货号：GS4483
产品规格：2μg

分子量：Approximately 15.4kDa,a single non-glycosylated polypeptide chain containing 133 amino acids.
储存条件：冷冻（-20℃）

概述

Human IL-21 is encoded by IL-21 gene located on Chr.4.It is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation and can regulating immune system cells,for instance cytotoxin T cells and natural killer cells.Additionally,it can induce target cells division or proliferation.IL-21 elicits its effect through binding to IL-21R,which also contains the gamma chain found in other cytokine receptors such as IL-2,IL-4,IL-7,IL-9 and IL-15.IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3,followed by activation of the transcription factors STAT1 and STAT3.IL-21 shows having much relation with clinical illnesses,including cancer immunotherapy,viral infections and allergies.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞97%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by by a cell proliferation assay using human N1186 T cells is less than 20ng/ml,corresponding to a specific activity of>5.0×104 IU/mg.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4.
内毒素	Less than 1 EU/μg of rHuIL-21 as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	QGQDRHMIRM RQLIDIVDQL KNYVNDLVPE FLPAPEDVET NCEWSAFSCF QKAQLKSANT GNNERIINVS IKKLKRKPPS TNAGRRQKHR LTCPSCDSYE KKPPKEFLER FKSLLQKMIH QHLSSRTHGS EDS

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