重组人CD3e蛋白|CD3e蛋白
基本信息
产品名称：
重组人CD3e蛋白|CD3e蛋白
英文名称：
Human CD3E Protein, mFc Tag
国产/进口：
国产
产地/品牌：
卡梅德生物科技（天津）有限公司
型号：
KMP2249
参考报价：
912
销售商：
总点击数：
870
更新日期：
2025-01-14
产品类别：
性能参数
产品编号: KMP2249
产品名称: Human CD3E Protein, mFc Tag
中文名称: 重组人CD3E蛋白
中文全称: 重组人T细胞表面糖蛋白CD3ε链蛋白
关键词: T细胞表面糖蛋白CD3ε链, T-Cell Surface Glycoprotein CD3 Epsilon Chain, T-Cell Surface Antigen T3/Leu-4 Epsilon Chain, CD3e, CD3E, T3E, Human CD3E Protein, mFc Tag, Recombinant Protein, KMP2249
物种: Human
宿主: HEK293 Cells
规格: 50ug, 100ug, 200ug
纯化方式: Affinity purification
纯度: >95% as determined by SDS-PAGE
内毒素水平: <1.0 EU/ug determined by the LAL method
缓冲体系: PBS, pH7.4
Uniprot: P07766
SDS-PAGE:
功能: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098).
In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128).
产品背景: T-Cell Surface Glycoprotein CD3 ε Chain(CD3ε) is a single-pass type I membrane protein. CD3ε contains 1 Ig-like(immunoglobulin-like) domain and 1 ITAM domain. CD3ε is a polypeptide encoded by the CD3E gene on chromosome 11 in humans. The T cell receptor-CD3 complex(TCR/CD3 complex) is involved in T-cell development and several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. The T cell receptor-CD3 complex is unique in having ten cytoplasmic immunoreceptor tyrosine-based activation motifs(ITAMs). TCR/CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.
保存条件: Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
运输条件: In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
说明: This product is for research use only.
具体参数链接: https://www.kmdbioscience.cn/
参考文献: 1.J. Immunol. 163:25-31 (1999)
2.J. Immunol. 173:2262-2270 (2004)
3.J. Clin. Invest. 114:1512-1517 (2004)
4.Proc. Natl. Acad. Sci. U.S.A. 86:3277-3281 (1989)
5.Int. Immunol. 28:127-137 (2016)
6.Nat. Genet. 3:77-81 (1993)
产品名称: Human CD3E Protein, mFc Tag
中文名称: 重组人CD3E蛋白
中文全称: 重组人T细胞表面糖蛋白CD3ε链蛋白
关键词: T细胞表面糖蛋白CD3ε链, T-Cell Surface Glycoprotein CD3 Epsilon Chain, T-Cell Surface Antigen T3/Leu-4 Epsilon Chain, CD3e, CD3E, T3E, Human CD3E Protein, mFc Tag, Recombinant Protein, KMP2249
物种: Human
宿主: HEK293 Cells
规格: 50ug, 100ug, 200ug
纯化方式: Affinity purification
纯度: >95% as determined by SDS-PAGE
内毒素水平: <1.0 EU/ug determined by the LAL method
缓冲体系: PBS, pH7.4
Uniprot: P07766
SDS-PAGE:
功能: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098).
In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128).
产品背景: T-Cell Surface Glycoprotein CD3 ε Chain(CD3ε) is a single-pass type I membrane protein. CD3ε contains 1 Ig-like(immunoglobulin-like) domain and 1 ITAM domain. CD3ε is a polypeptide encoded by the CD3E gene on chromosome 11 in humans. The T cell receptor-CD3 complex(TCR/CD3 complex) is involved in T-cell development and several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. The T cell receptor-CD3 complex is unique in having ten cytoplasmic immunoreceptor tyrosine-based activation motifs(ITAMs). TCR/CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.
保存条件: Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
运输条件: In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
说明: This product is for research use only.
具体参数链接: https://www.kmdbioscience.cn/
参考文献: 1.J. Immunol. 163:25-31 (1999)
2.J. Immunol. 173:2262-2270 (2004)
3.J. Clin. Invest. 114:1512-1517 (2004)
4.Proc. Natl. Acad. Sci. U.S.A. 86:3277-3281 (1989)
5.Int. Immunol. 28:127-137 (2016)
6.Nat. Genet. 3:77-81 (1993)
公司简介
天津卡梅德科技发展有限公司不断致力于成为领先的药物抗体发现及相关配套服务提供商。我们以技术研发为核心，为全球科学家和研究机构提供高品质的CRO（合同研究组织）服务，旨在推动医药科技的发展和创新。
作为一家高新技术企业，我们拥有国家专利试点单位和实验室ISO9001:2015质量管理体系认证，并荣获超过30项专利和4项注册商标。卡梅德生物的技术服务团队超过90%的人员为硕士以上学历，我们每年为国内外各类研究机构、医院、制药公司和生物公司提供近千件项技术服务咨询、方案设计以及项目交付。我们的核心服务平台包括抗体药物发现平台、抗体工程改造平台、稳定细胞系构建与菌株开发工艺平台、重组抗体和重组蛋白表达和纯化平台等。
除了专业的技术服务，卡梅德生物坚守着诚信、创新和卓越的价值观。我们将持续不断的技术创新视为公司发展的动力，致力于为客户提供最优质的解决方案。
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