特别提示：包括SARS-CoV-2 S蛋白中和抗体(小鼠IgG1)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：SARS-CoV-2 S蛋白中和抗体(小鼠IgG1)
英文名称：Anti-SARS-CoV-2 S Protein Neutralizing Antibody
产品货号：JN4035
产品规格：1mg

特异性：识别SARS-CoV-2 S蛋白/SARS-CoV-2 S-RBD，并阻断ACE-2受体结合。
同型：小鼠IgG1
来源：来自无动物源成分的体外培养
纯度：≥95%
浓度：2.0(±10%) mg/ml
贮存液：PBS,pH7.4
外观：液体，在存储期间可能会变得稍微不透明
保存条件：-20℃保存2年

免疫活性：


Immobilized Recombinant SARS-CoV-2 S-trimer Protein (C-6His) (Cat#JN2099) at 5.0μg/ml (100μL/well) can bind Anti-SARS-CoV-2 S Protein Antibody,the EC50 is less than 4.43ng/ml.


Immobilized Recombinant SARS-CoV-2 S Protein RBD-SD1 (C-6His) (Cat#JN2092) at 5.0μg/ml (100μL/well) can bind Anti-SARS-CoV-2 S Protein Antibody,the EC50 is less than 6.5ng/ml.


Anti-SARS-CoV-2 S Protein Antibody can block Human ACE-2-Avi-His (Cat#JN2062) and SARS-CoV-2 S-trimer Protein(Cat#JN2099) interaction,the IC50 for this effect is 80ng/ml.

背景资料：
The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process.Most notable is severe acute respiratory syndrome (SARS).The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion.It is also a major immunogen and a target for entry inhibitors.It"s been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor.The spike protein is a large type I transmembrane protein containing two subunits,S1 and S2.S1 mainly contains a receptor binding domain (RBD),which is responsible for recognizing the cell surface receptor.S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses,as well as protective immunity.

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