重组SARS-CoV-2 S-RBD(His标签)(＞95%)

特别提示：包括重组SARS-CoV-2 S-RBD(His标签)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组SARS-CoV-2 S-RBD(His标签)
英文名称：Recombinant SARS-CoV-2 Spike RBD Protein(C-6His)
产品货号：JN2086
产品规格：50μg|500μg|1mg

本制品由哺乳动物表达系统制备，目的基因编码表达SARS-CoV-2 Spike Protein RBD(Asn331-Val524)，C端带有一个6*His标签，用作免疫原或标准品。

Accession#：QHD43416.1
分子量：22.6kDa
实测分子量：28～35kDa
纯度：＞95%（还原性SDS-PAGE）
纯化方式：亲和色谱法
贮存液：PBS，pH7.4，0.2μm过滤
保存条件：-20℃。

生物活性：

Immobilized Human ACE-2-FC(货号：JN2061) at 10μg/ml (100μl/well) can bind SARS-CoV-2 Spike Protein RBD(货号：JN2086).The ED₅₀of SARS-CoV-2 Spike Protein RBD(货号：JN2086) is 460ng/mL

背景资料：
Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation,apoptosis,cancer development and progression,and the innate immune response.Known receptors bind S1 are ACE2,angiotensin-converting enzyme 2,DPP4,CEACAM etc..The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process.Most notable is severe acute respiratory syndrome (SARS).The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion.It is also a major immunogen and a target for entry inhibitors.It"s been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor.The spike protein is a large type I transmembrane protein containing two subunits,S1 and S2.S1 mainly contains a receptor binding domain (RBD),which is responsible for recognizing the cell surface receptor.S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses,as well as protective immunity.

根据您的关注的重组SARS-CoV-2 S-RBD(His标签)(＞95%)，重组SARS-CoV-2受体结合域，重组SARS-CoV-2 Spike RBD Protein(C-6His)，重组His标签，Recombinant SARS-CoV-2 Spike RBD Protein(C-6His)，重组新型冠状病毒刺突蛋白受体结合域，重组SARS-CoV-2 S-RBD，重组新冠病毒S蛋白RBD，您可能还对以下产品有需求：



名称：重组大鼠血管内皮生长因子A(VEGF-A)(VEGF164)
货号：JN0269
规格：10μg|50μg|500μg|1mg
本品由我们的酵母表达系统制备，目的基因编码的Ala27-Arg190表达纯化而来。

VEGF164质量控制：＞95%(还原性SDS-PAGE)。

VEGF164制剂：冻干品

VEGF164保存：
冻干蛋白可在-20℃长期保存，室温也可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天。
复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。

VEGF164复溶：
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存，避免反复冻融。

关于VEGF164：
Vascular endothelial growth factor (VEGF/VEGF-A ) is originally known as vascular permeability factor (VPF). It belongs to the PDGF family with a cysteine-knot structure comprised of eight conserved cysteine residues, and reckoned as a potent mediator in the process of angiogenesis and vasculogenesis in either fetus or adult. VEGF is particularly expressed in supraoptic , paraventricular nuclei and the choroid plexus of the pituitary, and abundant in the corpus luteum of the ovary and in kidney glomeruli. The rat VEGF protein contains a putative 20 amino acids (aa) signal peptide, and alternative splicing of rat VEGF gene produces isoforms of 120, 144, 164 and 188 aa. Rat VEGF164 respectively displays 97% and 88% aa identity with that regions of mouse and human VEGF. VEGF can bind to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin, and play important roles in inducing endothelial cell proliferation, promoting cell migration, inhibiting apoptosis and inducing permeabilization of blood vessels.

关注重组SARS-CoV-2 S-RBD(His标签)(＞95%)，重组SARS-CoV-2受体结合域，重组SARS-CoV-2 Spike RBD Protein(C-6His)，重组His标签，Recombinant SARS-CoV-2 Spike RBD Protein(C-6His)，重组新型冠状病毒刺突蛋白受体结合域，重组SARS-CoV-2 S-RBD，重组新冠病毒S蛋白RBD的同时，为您推荐更多您可能感兴趣的产品：

 

货号	名称	规格
JN0204	重组人GM-CSF(酵母表达)	10μg|50μg|500μg|1mg
JN0245	重组人VEGF-A(血管内皮生长因子A)(带His标签)	10μg|50μg|500μg|1mg
JN2031	重组人原肌球蛋白α1链(TPM1)	10μg|50μg|500μg|1mg
JN0636	重组人补体因子H相关蛋白1(CFHR1)	10μg|50μg|500μg|1mg
JN0838	重组人CGREF1	10μg|50μg|500μg|1mg
JN1037	重组人Resistin(RETN)(脂肪因子抵抗素)(ADSF)(脂肪组织特异分泌因子)	10μg|50μg|500μg|1mg