特别提示：包括重组SARS-CoV-2 S-RBD-SD1(His标签,V367F)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组SARS-CoV-2 S-RBD-SD1(His标签,V367F)
英文名称：Recombinant SARS-CoV-2 Spike Protein RBD-SD1(V367F, C-6His)
产品货号：JN3000
产品规格：50μg|500μg|1mg

本制品由哺乳动物表达系统制备，目的基因编码表达SARS-CoV-2 S-RBD-SD1(Arg319-Ser591(Val367Phe))，C端带有一个6*his标签，用作免疫原或标准品。

技术指标：
Accession#：QHD43416.1
分子量：31.4kDa
实测分子量：30-40kDa（还原条件下）
纯度：＞95%（还原性SDS-PAGE）
纯化方式：亲和色谱法
贮存液：PBS，pH7.4，0.2μm过滤
保存条件：-20℃。

背景资料：
Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation,apoptosis,cancer development and progression,and the innate immune response.Known receptors bind S1 are ACE2,angiotensin-converting enzyme 2,DPP4,CEACAM etc.The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process.Most notable is severe acute respiratory syndrome (SARS).The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion.It is also a major immunogen and a target for entry inhibitors.It"s been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor.The spike protein is a large type I transmembrane protein containing two subunits,S1 and S2.S1 mainly contains a receptor binding domain (RBD),which is responsible for recognizing the cell surface receptor.S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses,as well as protective immunity.

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