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CAS No. :

MCE 国际站：GPX4-IN-3

产品活性：GPX4-IN-3 (26a) 是有效的谷胱甘肽过氧化物酶4 (GPX4) 抑制剂，可选择性诱导铁死亡 (ferroptosis)。GPX4-IN-3 (26a) 在1 μM 的浓度可抑制GPX4 71.7% 活性。

研究领域：Metabolic Enzyme/Protease  |  Apoptosis

作用靶点：Glutathione Peroxidase  |  Ferroptosis

In Vitro: GPX4-IN-3 (26a) exhibits IC₅₀ values of 0.78 μM, 6.9 μM, 0.15 μM and 4.73 μM in 4T1, MCF-7, HT1080 and HT1080 (with Fer-1) cells, respectively.
GPX4-IN-3 (26a) exhibits outstanding GPX4 inhibitory activity with a percent inhibition up to 71.7% at 1.0 μM compared to 45.9% of RSL-3.
GPX4-IN-3 (26a) could significantly induce lipid peroxide (LPO) increase and effectively induce ferroptosis with satisfactory selectivity.
GPX4-IN-3 (26a) is more likely to induce ferroptosis through the accumulation of intracellular peroxides via inhibiting GPX4 activity.
GPX4-IN-3 (26a) significantly increased the level of ROS in 4T1 cells, which could also be reversed by Ferrostatin-1 (fer-1).

In Vivo: GPX4-IN-3 (26a) exertes antitumor activity and good biological safety in vivo.

相关产品：Bioactive Compound Library Plus  |  Erastin  |  Ferrostatin-1  |  Cisplatin  |  RSL3  |  Cycloheximide  |  Acetylcysteine  |  Deferoxamine mesylate  |  Sorafenib  |  SP600125  |  Necrostatin-1  |  ML385  |  Rosiglitazone  |  Liproxstatin-1  |  Roxadustat  |  Curcumin  |  Hemin  |  TBHQ  |  Lapatinib  |  (-)-Epigallocatechin Gallate  |  Simvastatin  |  U-73122  |  Bardoxolone methyl  |  Lovastatin  |  Trolox  |  Pifithrin-α hydrobromide  |  L-Glutathione reduced  |  Sulfasalazine  |  iFSP1  |  Eprenetapopt

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