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Verbascoside

CAS No. : 61276-17-3

MCE 国际站：Verbascoside

产品活性：Verbascoside 是从 Acanthus mollis 中得到的糖苷类物质，为 ATP 竞争性的 PKC 抑制剂，IC₅₀ 值为 25 M，具有抗肿瘤，抗炎，抗神经性疼痛等作用。

研究领域：Epigenetics  |  TGF-beta/Smad  |  Apoptosis  |  Anti-infection

作用靶点：PKC  |  Apoptosis  |  Bacterial  |  HSV

In Vitro: Verbascoside acts as an ATP-competitive inhibitor of PKC, with an IC₅₀ of 25 μM. Verbascoside shows K_is of 22 and 28 μM with respect to ATP and histone, respectively. Verbascoside has potent antitumor activity against L-1210 cells, with an IC₅₀ of 13 μM. Verbascoside (5, 10 μM) suppresses 2,4-dinitrochlorobenzene (DNCB)-induced T cell costimulatory factors CD86 and CD54, proinflammatory cytokines, and NFκB pathway activation in THP-1 cells.

In Vivo: Verbascoside (1%) reduces the overall scratching behavior incidence as well as the severity of the skin lesions in 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) mice model. Verbascoside also blocks DNCB-induced expression of proinflammatory cytokine TNF-α, IL-6, and IL-4 mRNA in skin lesions. Verbascoside (50, 100 mg/kg, i.p.) does not modify chronic constriction injury (CCI)-induced cold allodynia. Verbascoside (200 mg/kg, i.p.) decreases hyper-sensitivity to cold stimulus, acetone, on day 3 in rats. Verbascoside also significantly reduces behavioral changes associated with neuropathy. Moreover, Verbascoside decreases Bax and increases Bcl-2 on day 3.

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