Peiminine | 贝母素乙

MCE 国际站：Peiminine

中文名：贝母素乙

CAS：18059-10-4

品牌：MedChemExpress (MCE)

存储条件：Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

生物活性：Peiminine(Verticinone; Raddeanine) 是一种具有抗炎活性的天然化合物。 IC50 值： 目标：Peiminine 和 DXS 显着降低博来霉素诱导的肺损伤大鼠的肺泡炎症和肺间质炎症。 peiminine 通过降低循环 IFN-γ 水平和抑制涉及 TGF-β、CTGF、ERK1/2、NF-κB 和 FasL 的信号转导通路，在博来霉素诱导的肺损伤大鼠模型中抑制肺部炎症和肺纤维化。

体外：Peiminine (2-6 μg/mL, 24 h) 可降低 HepG2 细胞中 procaspase-3、procaspase- 8、procaspase -9 的表达，提高 caspase-3、8、9 蛋白水平[1]。 Peiminine (2-14 μg/mL, 24-72 h) 对 HepG2、Hela、SW480 和 MCF-7 细胞有明显的细胞毒性作用[1]。 Peiminine (2-6 μg/mL, 24 h) 诱导 HepG2 细胞凋亡[1]。 Peiminine (2-6 μg/mL, 24 h) 诱导 HepG2 细胞阻滞于 G2/M 期[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内：Peiminine (3mg/kg, intraperitoneal injection, single dose) 可减轻溃疡性结肠炎实验模型的炎症表现，减轻肠组织损伤[2]。 Peiminine (10 mg/kg, Intraperitoneal injection, once every 2 days for 6 weeks) 可预防 OVX 诱导的大鼠骨量丢失和脂肪形成[3]。 Peiminine (1-5 mg/kg, are applied to the dorsal skin, once daily for 16 days) 抑制血清中的 IL-6 和 TNF-α 在 DNCB 诱导的过敏性皮炎动物模型中[4]。 Peiminine (2-5 mg/kg, Intraperitoneal injection, once a day for 4 weeks) 对心肌梗死大鼠心肌损伤和纤维化具有保护作用[5]。 Peiminine (1-5 mg/kg, Intraperitoneal injection, single dose) 可在脂多糖诱导的急性肺损伤模型小鼠中减轻炎症反应对机体的损伤和肺水肿的可能性[6]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: ulcerative colitis model[2] Dosage: 3mg/kg Administration: Intraperitoneal injection (i.p.) Result: Reduced inflammation, mucosal ulcers, involvement of digestive system layers, and infltration of inflammatory cells. Reduced the levels of MPO and NO generated in the rectal tissue. Reduced cell proliferation in spleen cell. Decreased the production of f IL-1β, IL-6, and TNF-α cytokines. Reduced expression levels of genes IL-1β, IL-6, TNF-α, iNOS, and COX2. Animal Model: Ovariectomized (OVX) rat model[3] Dosage: 10 mg/kg Administration: Intraperitoneal injection (i.p.) Result: Alleviated the bone loss caused by surgical castration. Improved the expression of COL1A1 and β-catenin and reduced the increase expression of PPAR-γ in trabecular bone. Animal Model: Allergic dermatitis model[4] Dosage: 1 mg/kg, 5 mg/kg Administration: were applied to the dorsal skin Result: Alleviated the bone loss caused by surgical castration. Improved the expression of COL1A1 and β-catenin and reduced the increase expression of PPAR-γ in trabecular bone.

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研究领域：Autophagy  |  Apoptosis  |  Cell Cycle/DNA Damage  |  Epigenetics  |  MAPK/ERK Pathway  |  Stem Cell/Wnt  |  NF-κB

作用靶点：Autophagy  |  Caspase  |  Bcl-2 Family  |  PARP  |  p38 MAPK  |  ERK  |  NF-κB  |  Apoptosis

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参考文献：

[1]. Guo H, et al. Peiminine ameliorates bleomycin-induced acute lung injury in rats. Mol Med Rep. 2013 Apr;7(4):1103-10.[2]. Chao X, et al. The effects and mechanism of peiminine-induced apoptosis in human hepatocellular carcinoma HepG2 cells [J]. PLoS One, 2019, 14(1): e0201864.[3]. Ranjbar Bushehri M, et al. Anti-inflammatory activity of peiminine in acetic acid-induced ulcerative colitis model [J]. Inflammopharmacology, 2023: 1-9.[4]. Gu H, et al. Peiminine regulates bone-fat balance by canonical Wnt/β-catenin pathway in an ovariectomized rat mode [J]. Phytotherapy Research, 2023.[5]. Lim J M, et al. Effect of peiminine on DNCB-induced atopic dermatitis by inhibiting inflammatory cytokine expression in vivo and in vitro [J]. International immunopharmacology, 2018, 56: 135-142.[6]. Chen P, et al. Peiminine inhibits myocardial injury and fibrosis after myocardial infarction in rats by regulating mitogen-activated protein kinase pathway [J]. The Korean Journal of Physiology & Pharmacology: Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2022, 26(2): 87-94.[7]. Du B, et al. Peiminine attenuates acute lung injury induced by LPS through inhibiting lipid rafts formation [J]. Inflammation, 2020, 43: 1110-1119.