Taspoglutide
基本信息
产品名称：
Taspoglutide
英文名称：
Taspoglutide
国产/进口：
进口
产地/品牌：
美国/TargetMol
型号：
参考报价：
面议
销售商：
总点击数：
46
更新日期：
2025-05-27
产品类别：
性能参数
Product Introduction
Bioactivity
英文名: Taspoglutide
描述: Taspoglutide is a long-acting glucagon-like peptide 1 (GLP-1) receptor agonist(EC50 value of 0.06 nM),and for treatment of type 2 diabetes
体外活性: Taspoglutide (R1583/BIM51077) with 93% homology with the native polypeptide, and is a long acting 10% formulation of (Aib8-35) human GLP-1 (7-36 amides) . It activates the GLP-1 receptor. Taspoglutide has comparable affinity (affinity constant 1.1±0.2 nM) to the natural ligand affinity constant 1.5±0.3 nM for the hGLP-1 receptor and exhibits comparable potency in stimulating cAMP production[2].
体内活性: The rate of glucose-induced insulin secretion from isolated enhanced by Taspoglutide, cultured rat islets and the perfused ZDF rat pancreas. Taspoglutide showed dose-dependent enhancement of glucose-dependent insulin release in Sprague-Dawley rats and diabetic db/db mice, thereby reducing blood glucose in the type 2 diabetic db/db mouse model[3]. Acute treatment with taspoglutide reduces glucose excursion and increased insulin response during oGTT. In chronically treated rats, glucose excursion and levels of GIP, PYY and triglycerides during oGTT on day 21 are significantly reduced[4]. Hepatic triglyceride levels are significantly reduced in livers from taspoglutide-treated. Taspoglutide does not reduce plaque area or lipid content in the aortic arch or abdominal aorta, and no significant change in aortic macrophage accumulation is detected after taspoglutide or metformin mice[5].
存储条件: keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 28 mg/mL (8.38 mM)
关键字: R 1583 | R-1583 | BIM 51077 | ITM 077 | BIM-51077 | Taspoglutide | ITM-077
Bioactivity
英文名: Taspoglutide
描述: Taspoglutide is a long-acting glucagon-like peptide 1 (GLP-1) receptor agonist(EC50 value of 0.06 nM),and for treatment of type 2 diabetes
体外活性: Taspoglutide (R1583/BIM51077) with 93% homology with the native polypeptide, and is a long acting 10% formulation of (Aib8-35) human GLP-1 (7-36 amides) . It activates the GLP-1 receptor. Taspoglutide has comparable affinity (affinity constant 1.1±0.2 nM) to the natural ligand affinity constant 1.5±0.3 nM for the hGLP-1 receptor and exhibits comparable potency in stimulating cAMP production[2].
体内活性: The rate of glucose-induced insulin secretion from isolated enhanced by Taspoglutide, cultured rat islets and the perfused ZDF rat pancreas. Taspoglutide showed dose-dependent enhancement of glucose-dependent insulin release in Sprague-Dawley rats and diabetic db/db mice, thereby reducing blood glucose in the type 2 diabetic db/db mouse model[3]. Acute treatment with taspoglutide reduces glucose excursion and increased insulin response during oGTT. In chronically treated rats, glucose excursion and levels of GIP, PYY and triglycerides during oGTT on day 21 are significantly reduced[4]. Hepatic triglyceride levels are significantly reduced in livers from taspoglutide-treated. Taspoglutide does not reduce plaque area or lipid content in the aortic arch or abdominal aorta, and no significant change in aortic macrophage accumulation is detected after taspoglutide or metformin mice[5].
存储条件: keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 28 mg/mL (8.38 mM)
关键字: R 1583 | R-1583 | BIM 51077 | ITM 077 | BIM-51077 | Taspoglutide | ITM-077
公司简介
TargetMol（陶术）作为一家全球性的生物医药领域高科技企业，我们致力于为高校、研究所、医院、企业等各类生物医药研发机构提供优质的产品和服务，为全球医药科学家更高效地完成科研工作助力。可提供20,000+种 抑制剂和激动剂 、800+种 化合物库 、19,000+种 天然产物 ，以及9,000+种 重组蛋白 、多种 多肽 、抗体 和 生命科学试剂盒 等。此外，在上海，TargetMol研发中心配备了 CADD & AIDD研究中心、药理实验室和药物化学合成 平台三大技术中心，可提供虚拟筛选、化合物活性测试、分子间结合力检测和化合物结构优化等技术服务，多方位满足用户的研发需求。
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