MSC2360844 hemifumarate
基本信息
产品名称：
MSC2360844 hemifumarate
英文名称：
MSC2360844 hemifumarate
国产/进口：
进口
产地/品牌：
美国/TargetMol
型号：
参考报价：
面议
销售商：
总点击数：
38
更新日期：
2025-05-27
产品类别：
性能参数
Product Introduction
Bioactivity
英文名: MSC2360844 hemifumarate
描述: MSC2360844 hemifumarate is a highly potent and orally active compound that acts as a selective inhibitor of PI3Kδ, with an IC50 value of 145 nM. This compound exhibits exceptional selectivity against a comprehensive panel of 278 additional kinases.
体外活性: MSC2360844 hemifumarate (0-10 μM; 1 hours) completely abolished BCR-induced pAkt in Ramos B cells in a concentration-dependent manner with IC 50 values of 280?nM[1]. MSC2360844 hemifumarate inhibits B cell proliferation in a concentration-dependent manner with an IC 50 of 48?nM. MSC2360844 hemifumarate blocks BCR- and TCR-mediated responses in lymphocytes and TLR-induced IFNα by pDC in human primary cells[1]. Cell Viability Assay[1]Cell Line: B cells Concentration: 0-10 μM Incubation Time: 1 hour Result: Inhibited B cell proliferation in a concentration-dependent manner with an IC 50 of 48 nM.
体内活性: MSC2360844 hemifumarate (6.6-66 mg/kg; daily from week 2 to 10) ameliorates disease manifestations in a murine SLE model[1]. Animal Model: NZB/W F1 female mice[1]Dosage: 6.6, 22, or 66?mg/kg Administration: Oral; starting at week 2 post ADV-IFNα delivery, once daily at 10?weeks Result: Significantly reduced proteinuria incidence and severity in a dose-dependent manner.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: MSC2360844 Hemifumarate | MSC2360844 hemifumarate | MSC 2360844 Hemifumarate | MSC-2360844 Hemifumarate | MSC2360844 | MSC-2360844 hemifumarate | MSC-2360844 | MSC 2360844
Bioactivity
英文名: MSC2360844 hemifumarate
描述: MSC2360844 hemifumarate is a highly potent and orally active compound that acts as a selective inhibitor of PI3Kδ, with an IC50 value of 145 nM. This compound exhibits exceptional selectivity against a comprehensive panel of 278 additional kinases.
体外活性: MSC2360844 hemifumarate (0-10 μM; 1 hours) completely abolished BCR-induced pAkt in Ramos B cells in a concentration-dependent manner with IC 50 values of 280?nM[1]. MSC2360844 hemifumarate inhibits B cell proliferation in a concentration-dependent manner with an IC 50 of 48?nM. MSC2360844 hemifumarate blocks BCR- and TCR-mediated responses in lymphocytes and TLR-induced IFNα by pDC in human primary cells[1]. Cell Viability Assay[1]Cell Line: B cells Concentration: 0-10 μM Incubation Time: 1 hour Result: Inhibited B cell proliferation in a concentration-dependent manner with an IC 50 of 48 nM.
体内活性: MSC2360844 hemifumarate (6.6-66 mg/kg; daily from week 2 to 10) ameliorates disease manifestations in a murine SLE model[1]. Animal Model: NZB/W F1 female mice[1]Dosage: 6.6, 22, or 66?mg/kg Administration: Oral; starting at week 2 post ADV-IFNα delivery, once daily at 10?weeks Result: Significantly reduced proteinuria incidence and severity in a dose-dependent manner.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: MSC2360844 Hemifumarate | MSC2360844 hemifumarate | MSC 2360844 Hemifumarate | MSC-2360844 Hemifumarate | MSC2360844 | MSC-2360844 hemifumarate | MSC-2360844 | MSC 2360844
公司简介
TargetMol（陶术）作为一家全球性的生物医药领域高科技企业，我们致力于为高校、研究所、医院、企业等各类生物医药研发机构提供优质的产品和服务，为全球医药科学家更高效地完成科研工作助力。可提供20,000+种 抑制剂和激动剂 、800+种 化合物库 、19,000+种 天然产物 ，以及9,000+种 重组蛋白 、多种 多肽 、抗体 和 生命科学试剂盒 等。此外，在上海，TargetMol研发中心配备了 CADD & AIDD研究中心、药理实验室和药物化学合成 平台三大技术中心，可提供虚拟筛选、化合物活性测试、分子间结合力检测和化合物结构优化等技术服务，多方位满足用户的研发需求。
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