L-白雀木醇
基本信息
产品名称：
L-白雀木醇
英文名称：
L-quebrachitol
国产/进口：
进口
产地/品牌：
美国/TargetMol
型号：
参考报价：
面议
销售商：
总点击数：
48
更新日期：
2025-05-27
产品类别：
性能参数
Product Introduction
Bioactivity
英文名: L-quebrachitol
描述: L-Quebrachitol 是一种从多种植物中分离得到的天然产物，能够触发 BMP-2 反应以及 Runx2、MAPK 和 Wnt/β-catenin 信号通路，诱导成骨细胞生成。
细胞实验: The total RNA from cells treated with l-quebrachitol was extracted using the TriPure Isolation Reagent .RNA (1 μg) was reverse transcribed using the Transcriptor First Strand cDNA Synthesis Kit to cDNA.The qRT-PCR analysis was performed using the EvaGreen HRM Mix .GAPDH was used as an internal control.The relative expression ratio was calculated using the 2^?△△Ct method.
体外活性: L-quebrachitol significantly promotes proliferation and cell DNA synthesis. It also enhances mineralization accompanied by increases in mRNA expression of bone matrix proteins including alkaline phosphatase (ALP), collagen type I (ColI), osteocalcin (OCN), and osteopontin (OPN). In addition, l-quebrachitol upregulates the mRNA and protein expression of bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2), while down-regulating the receptor activator of the nuclear factor-κB ligand (RANKL) mRNA level. Moreover, the expression of regulatory genes associated with the mitogen-activated protein kinase (MAPK) and wingless-type MMTV integration site (Wnt)/β-catenin signaling pathways are also upregulated.L-quebrachitol may promote osteoblastogenesis by triggering the BMP-2-response as well as the Runx2, MAPK, and Wnt/β-catenin signaling pathway.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 22.5 mg/mL (115.87 mM)
关键字: Beta catenin | Wnt | L quebrachitol | Inhibitor | L-quebrachitol | Lquebrachitol | L-Quebrachitol | inhibit | β-catenin
相关产品: ICG001 | WAY-262611 | Excisanin A | Astragaloside I | TNIK-IN-7 | K-756 | TNKS-2-IN-1 | iCRT-5 | NRX-103094 | KY1220
相关库: Anti-Inflammatory Traditional Chinese Medicine Compound Library | Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library | Anti-Cancer Metabolism Compound Library | Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library | Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS | RO5 Drug-like Natural Product Library | Reprogramming Compound Library | Natural Product Library
Bioactivity
英文名: L-quebrachitol
描述: L-Quebrachitol 是一种从多种植物中分离得到的天然产物，能够触发 BMP-2 反应以及 Runx2、MAPK 和 Wnt/β-catenin 信号通路，诱导成骨细胞生成。
细胞实验: The total RNA from cells treated with l-quebrachitol was extracted using the TriPure Isolation Reagent .RNA (1 μg) was reverse transcribed using the Transcriptor First Strand cDNA Synthesis Kit to cDNA.The qRT-PCR analysis was performed using the EvaGreen HRM Mix .GAPDH was used as an internal control.The relative expression ratio was calculated using the 2^?△△Ct method.
体外活性: L-quebrachitol significantly promotes proliferation and cell DNA synthesis. It also enhances mineralization accompanied by increases in mRNA expression of bone matrix proteins including alkaline phosphatase (ALP), collagen type I (ColI), osteocalcin (OCN), and osteopontin (OPN). In addition, l-quebrachitol upregulates the mRNA and protein expression of bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2), while down-regulating the receptor activator of the nuclear factor-κB ligand (RANKL) mRNA level. Moreover, the expression of regulatory genes associated with the mitogen-activated protein kinase (MAPK) and wingless-type MMTV integration site (Wnt)/β-catenin signaling pathways are also upregulated.L-quebrachitol may promote osteoblastogenesis by triggering the BMP-2-response as well as the Runx2, MAPK, and Wnt/β-catenin signaling pathway.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 22.5 mg/mL (115.87 mM)
关键字: Beta catenin | Wnt | L quebrachitol | Inhibitor | L-quebrachitol | Lquebrachitol | L-Quebrachitol | inhibit | β-catenin
相关产品: ICG001 | WAY-262611 | Excisanin A | Astragaloside I | TNIK-IN-7 | K-756 | TNKS-2-IN-1 | iCRT-5 | NRX-103094 | KY1220
相关库: Anti-Inflammatory Traditional Chinese Medicine Compound Library | Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library | Anti-Cancer Metabolism Compound Library | Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library | Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS | RO5 Drug-like Natural Product Library | Reprogramming Compound Library | Natural Product Library
公司简介
TargetMol（陶术）作为一家全球性的生物医药领域高科技企业，我们致力于为高校、研究所、医院、企业等各类生物医药研发机构提供优质的产品和服务，为全球医药科学家更高效地完成科研工作助力。可提供20,000+种 抑制剂和激动剂 、800+种 化合物库 、19,000+种 天然产物 ，以及9,000+种 重组蛋白 、多种 多肽 、抗体 和 生命科学试剂盒 等。此外，在上海，TargetMol研发中心配备了 CADD & AIDD研究中心、药理实验室和药物化学合成 平台三大技术中心，可提供虚拟筛选、化合物活性测试、分子间结合力检测和化合物结构优化等技术服务，多方位满足用户的研发需求。
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