Iadademstat dihydrochloride
基本信息
产品名称：
Iadademstat dihydrochloride
英文名称：
Iadademstat dihydrochloride
国产/进口：
进口
产地/品牌：
美国/TargetMol
型号：
参考报价：
面议
销售商：
总点击数：
26
更新日期：
2025-05-27
产品类别：
性能参数
Product Introduction
Bioactivity
英文名: Iadademstat dihydrochloride
描述: Iadademstat dihydrochloride (ORY-1001(trans)) 是一种不可逆的选择性赖氨酸特异性脱甲基酶 1A(KDM1A/LSD1) 抑制剂，用于治疗急性白血病。
体外活性: ORY-1001 is a highly potent and selective KDM1A inhibitor that induces H3K4me2 accumulation on KDM1A target genes, blast differentiation, and reduction of leukemic stem cell capacity in AML.
体内活性: ORY-1001 exhibits potent synergy with standard-of-care drugs and selective epigenetic inhibitors, reduces growth of an AML xenograft model, and extends survival in a mouse PDX (patient-derived xenograft) model of T cell acute leukemia.?Surrogate pharmacodynamic biomarkers developed based on expression changes in leukemia cell lines were translated to samples from patients treated with ORY-1001.?ORY-1001 is a selective KDM1A inhibitor in clinical trials and is currently being evaluated in patients with leukemia and solid tumors.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 3.03 mg/mL (10 mM)
关键字: RO 7051790 | RG 6016 | Iadademstat dihydrochloride | Histone Demethylase | RO7051790 | inhibit | RG6016 | Inhibitor | ORY1001 | RO-7051790 | ORY 1001 | Iadademstat Dihydrochloride | ORY-1001 | Iadademstat | RG-6016
相关产品: LSD1-IN-5 | Procaine | Procaine hydrochloride | T-3775440 hydrochloride | LSD1-IN-30 | GSK 690 Hydrochloride | GSK2879552 | Corin | ML324 | Vafidemstat
相关库: Drug Repurposing Compound Library | Anti-Cancer Drug Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Cancer Clinical Compound Library | Inhibitor Library | Anti-Cancer Active Compound Library | Stem Cell Differentiation Compound Library | Preclinical Compound Library | Histone Modification Compound Library
Bioactivity
英文名: Iadademstat dihydrochloride
描述: Iadademstat dihydrochloride (ORY-1001(trans)) 是一种不可逆的选择性赖氨酸特异性脱甲基酶 1A(KDM1A/LSD1) 抑制剂，用于治疗急性白血病。
体外活性: ORY-1001 is a highly potent and selective KDM1A inhibitor that induces H3K4me2 accumulation on KDM1A target genes, blast differentiation, and reduction of leukemic stem cell capacity in AML.
体内活性: ORY-1001 exhibits potent synergy with standard-of-care drugs and selective epigenetic inhibitors, reduces growth of an AML xenograft model, and extends survival in a mouse PDX (patient-derived xenograft) model of T cell acute leukemia.?Surrogate pharmacodynamic biomarkers developed based on expression changes in leukemia cell lines were translated to samples from patients treated with ORY-1001.?ORY-1001 is a selective KDM1A inhibitor in clinical trials and is currently being evaluated in patients with leukemia and solid tumors.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 3.03 mg/mL (10 mM)
关键字: RO 7051790 | RG 6016 | Iadademstat dihydrochloride | Histone Demethylase | RO7051790 | inhibit | RG6016 | Inhibitor | ORY1001 | RO-7051790 | ORY 1001 | Iadademstat Dihydrochloride | ORY-1001 | Iadademstat | RG-6016
相关产品: LSD1-IN-5 | Procaine | Procaine hydrochloride | T-3775440 hydrochloride | LSD1-IN-30 | GSK 690 Hydrochloride | GSK2879552 | Corin | ML324 | Vafidemstat
相关库: Drug Repurposing Compound Library | Anti-Cancer Drug Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Cancer Clinical Compound Library | Inhibitor Library | Anti-Cancer Active Compound Library | Stem Cell Differentiation Compound Library | Preclinical Compound Library | Histone Modification Compound Library
公司简介
TargetMol（陶术）作为一家全球性的生物医药领域高科技企业，我们致力于为高校、研究所、医院、企业等各类生物医药研发机构提供优质的产品和服务，为全球医药科学家更高效地完成科研工作助力。可提供20,000+种 抑制剂和激动剂 、800+种 化合物库 、19,000+种 天然产物 ，以及9,000+种 重组蛋白 、多种 多肽 、抗体 和 生命科学试剂盒 等。此外，在上海，TargetMol研发中心配备了 CADD & AIDD研究中心、药理实验室和药物化学合成 平台三大技术中心，可提供虚拟筛选、化合物活性测试、分子间结合力检测和化合物结构优化等技术服务，多方位满足用户的研发需求。
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