乙基双亚氨基甲基愈创木酚锰氯化物
基本信息
产品名称：
乙基双亚氨基甲基愈创木酚锰氯化物
英文名称：
EUK-134
国产/进口：
进口
产地/品牌：
美国/TargetMol
型号：
参考报价：
面议
销售商：
总点击数：
37
更新日期：
2025-05-27
产品类别：
性能参数
Product Introduction
Bioactivity
英文名: EUK-134
描述: EUK-134 是合成的超氧化物歧化酶和过氧化氢酶模拟物，可保护大鼠肾脏免受缺血再灌注引起的损伤。它作用于 H9C2 细胞，降低NF-κB 表达、MDA 水平和蛋白质羰基化。它是具有过氧化氢酶活性的超氧化物歧化酶 (SOD) 模拟物 (SODm)。它是保护有丝分裂的抗氧化剂。
体外活性: EUK 134 shows potent catalase and SOD activities, and protects human fibroblasts against cytotoxicity by glucose and glucose oxidase. [1] EUK 134 (20 μM) prevents Aβ-induced microglial proliferation in vitro. [2] In SK-N-MC cells, EUK134 protects neuronal cells against H(2)O(2) toxicity by attenuating oxidative stress through inhibition of MAPK pathway, and also results in decreased expression of pro-apoptotic genes p53 and Bax as well as enhanced expression of anti-apoptotic Bcl-2 gene. [3] EUK 134 significantly inhibits amyloid formation at two molar ratios of 1:1 and 5:1 (drugs to protein). [4]
体内活性: EUK 134 (2.5 mg/kg), in a middle cerebral artery occlusion model, significantly reduces brain infarct size, and apparently prevents further infarct growth. [1] EUK-134 prevents oxidative stress and attenuates rat brain damage induced by systemic administration of systemic kainic acid (KA). [5]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 77 mg/mL (184.8 mM)
H2O : 11 mg/mL (26.4 mM)
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
关键字: Inhibitor | Free | mitoprotective | Nephrotoxicity | antioxidant | SODm | species | Nuclear factor-kappaB | NRK-52E | EUK-134 | radicals | NF-κB | inhibit | oxygen | Nuclear factor-κB | catalase | Reactive | EUK134 | Superoxide | mimetic | SOD | dismutase
相关产品: BMS 433796 | δ-secretase inhibitor 11 | Ginsenoside Rg1 | Amyloid β Peptide (42-1)(human) acetate | β-Amyrin | Lecanemab | Hederacolchiside E | Itanapraced | Isorosmanol | V-9-M Cholecystokinin nonapeptide
相关库: Antioxidant Compound Library | Anti-Neurodegenerative Disease Compound Library | Oxidation-Reduction Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Ferroptosis Compound Library | Inhibitor Library | Cuproptosis Compound Library | Preclinical Compound Library | Bioactive Compound Library
Bioactivity
英文名: EUK-134
描述: EUK-134 是合成的超氧化物歧化酶和过氧化氢酶模拟物，可保护大鼠肾脏免受缺血再灌注引起的损伤。它作用于 H9C2 细胞，降低NF-κB 表达、MDA 水平和蛋白质羰基化。它是具有过氧化氢酶活性的超氧化物歧化酶 (SOD) 模拟物 (SODm)。它是保护有丝分裂的抗氧化剂。
体外活性: EUK 134 shows potent catalase and SOD activities, and protects human fibroblasts against cytotoxicity by glucose and glucose oxidase. [1] EUK 134 (20 μM) prevents Aβ-induced microglial proliferation in vitro. [2] In SK-N-MC cells, EUK134 protects neuronal cells against H(2)O(2) toxicity by attenuating oxidative stress through inhibition of MAPK pathway, and also results in decreased expression of pro-apoptotic genes p53 and Bax as well as enhanced expression of anti-apoptotic Bcl-2 gene. [3] EUK 134 significantly inhibits amyloid formation at two molar ratios of 1:1 and 5:1 (drugs to protein). [4]
体内活性: EUK 134 (2.5 mg/kg), in a middle cerebral artery occlusion model, significantly reduces brain infarct size, and apparently prevents further infarct growth. [1] EUK-134 prevents oxidative stress and attenuates rat brain damage induced by systemic administration of systemic kainic acid (KA). [5]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 77 mg/mL (184.8 mM)
H2O : 11 mg/mL (26.4 mM)
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
关键字: Inhibitor | Free | mitoprotective | Nephrotoxicity | antioxidant | SODm | species | Nuclear factor-kappaB | NRK-52E | EUK-134 | radicals | NF-κB | inhibit | oxygen | Nuclear factor-κB | catalase | Reactive | EUK134 | Superoxide | mimetic | SOD | dismutase
相关产品: BMS 433796 | δ-secretase inhibitor 11 | Ginsenoside Rg1 | Amyloid β Peptide (42-1)(human) acetate | β-Amyrin | Lecanemab | Hederacolchiside E | Itanapraced | Isorosmanol | V-9-M Cholecystokinin nonapeptide
相关库: Antioxidant Compound Library | Anti-Neurodegenerative Disease Compound Library | Oxidation-Reduction Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Ferroptosis Compound Library | Inhibitor Library | Cuproptosis Compound Library | Preclinical Compound Library | Bioactive Compound Library
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