四烯甲萘醌
基本信息
产品名称：
四烯甲萘醌
英文名称：
Menaquinone-4
国产/进口：
进口
产地/品牌：
美国/TargetMol
型号：
参考报价：
面议
销售商：
总点击数：
54
更新日期：
2025-05-27
产品类别：
性能参数
Product Introduction
Bioactivity
英文名: Menaquinone-4
描述: Menaquinone-4 (Vitamin K2) 是维生素 K 的一种，用作止血剂，有潜力用于骨质疏松的研究。
动物实验: Forty-two male, 4-week-old C57BL/6J mice.?an automated constant-temperature humidity system was used to maintain a temperature of 23°C ± 2°C and humidity of 60% ± 3% for the animals.?The animals were provided with feed and drink ad libitum.?For environmental adaptation, the animals had 1 week of circulation, and then were provided with the experimental diet after being randomly divided into 6 groups (7 animals in each group;?randomized block design).?The AIN-93G diets consisted of a normal diet (N), normal diet + vitamin K1 (N-K1), normal diet + vitamin K2 (N-K2), 45% high-fat diet (HF), 45% high-fat diet + vitamin K1 (HF-K1), and a 45% high-fat diet + vitamin K2 (HF-K2).?The vitamin K1 and vitamin K2 contents were 200 mg/1,000 g, and the diet was provided in pellet form.?Food intake amount was measured every other day.?Body weight was measured once a week, and the food efficiency ratio (FER) was calculated by dividing the increased body weight from day1 to the final day by the food intake amount during the experiment period.?For fat amount measurement, the epididymal fat, perirenal fat, and retroperitoneal fat were extracted from dead animal subjects, were washed with 0.9% NaCl, dried by filter paper, and then were weighed[1].
体内活性: Vitamin K 补充逆转了高脂饮食引起的骨质退化，通过调节成骨细胞和破骨细胞的活性，并在高脂饮食诱导的肥胖小鼠中防止骨质流失[1]。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 4.45 mg/mL (10 mM)
关键字: Menaquinone 4 | Vitamin K2(MK-4) | inhibit | Inhibitor | Menaquinone K-4 | Menaquinone-4 | Endogenous Metabolite | Menaquinone K 4 | Menaquinone4
相关产品: L-Cystathionine | (2-Aminoethyl)phosphonic acid | 3-Methoxytyramine hydrochloride | MAHMA NONOate | Oxytetracycline Dihydrate | Flavin adenine dinucleotide disodium salt | Maltol | Normetanephrine hydrochloride | D-Glucose 6-phosphate disodium salt | p-Hydroxybenzaldehyde
相关库: Anti-Tumor Natural Product Library | Drug Repurposing Compound Library | Approved Drug Library | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compounds Library Max | Human Endogenous Metabolite Compound Library Plus | Natural Product Library for HTS | Microbial Natural Product Library | Gut Microbial Metabolite Library | Bioactive Compound Library
Bioactivity
英文名: Menaquinone-4
描述: Menaquinone-4 (Vitamin K2) 是维生素 K 的一种，用作止血剂，有潜力用于骨质疏松的研究。
动物实验: Forty-two male, 4-week-old C57BL/6J mice.?an automated constant-temperature humidity system was used to maintain a temperature of 23°C ± 2°C and humidity of 60% ± 3% for the animals.?The animals were provided with feed and drink ad libitum.?For environmental adaptation, the animals had 1 week of circulation, and then were provided with the experimental diet after being randomly divided into 6 groups (7 animals in each group;?randomized block design).?The AIN-93G diets consisted of a normal diet (N), normal diet + vitamin K1 (N-K1), normal diet + vitamin K2 (N-K2), 45% high-fat diet (HF), 45% high-fat diet + vitamin K1 (HF-K1), and a 45% high-fat diet + vitamin K2 (HF-K2).?The vitamin K1 and vitamin K2 contents were 200 mg/1,000 g, and the diet was provided in pellet form.?Food intake amount was measured every other day.?Body weight was measured once a week, and the food efficiency ratio (FER) was calculated by dividing the increased body weight from day1 to the final day by the food intake amount during the experiment period.?For fat amount measurement, the epididymal fat, perirenal fat, and retroperitoneal fat were extracted from dead animal subjects, were washed with 0.9% NaCl, dried by filter paper, and then were weighed[1].
体内活性: Vitamin K 补充逆转了高脂饮食引起的骨质退化，通过调节成骨细胞和破骨细胞的活性，并在高脂饮食诱导的肥胖小鼠中防止骨质流失[1]。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 4.45 mg/mL (10 mM)
关键字: Menaquinone 4 | Vitamin K2(MK-4) | inhibit | Inhibitor | Menaquinone K-4 | Menaquinone-4 | Endogenous Metabolite | Menaquinone K 4 | Menaquinone4
相关产品: L-Cystathionine | (2-Aminoethyl)phosphonic acid | 3-Methoxytyramine hydrochloride | MAHMA NONOate | Oxytetracycline Dihydrate | Flavin adenine dinucleotide disodium salt | Maltol | Normetanephrine hydrochloride | D-Glucose 6-phosphate disodium salt | p-Hydroxybenzaldehyde
相关库: Anti-Tumor Natural Product Library | Drug Repurposing Compound Library | Approved Drug Library | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compounds Library Max | Human Endogenous Metabolite Compound Library Plus | Natural Product Library for HTS | Microbial Natural Product Library | Gut Microbial Metabolite Library | Bioactive Compound Library
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TargetMol（陶术）作为一家全球性的生物医药领域高科技企业，我们致力于为高校、研究所、医院、企业等各类生物医药研发机构提供优质的产品和服务，为全球医药科学家更高效地完成科研工作助力。可提供20,000+种 抑制剂和激动剂 、800+种 化合物库 、19,000+种 天然产物 ，以及9,000+种 重组蛋白 、多种 多肽 、抗体 和 生命科学试剂盒 等。此外，在上海，TargetMol研发中心配备了 CADD & AIDD研究中心、药理实验室和药物化学合成 平台三大技术中心，可提供虚拟筛选、化合物活性测试、分子间结合力检测和化合物结构优化等技术服务，多方位满足用户的研发需求。
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