伊布莫仑甲磺酸盐
基本信息
产品名称：
伊布莫仑甲磺酸盐
英文名称：
Ibutamoren Mesylate
国产/进口：
进口
产地/品牌：
美国/TargetMol
型号：
参考报价：
面议
销售商：
总点击数：
34
更新日期：
2025-05-27
产品类别：
性能参数
Product Introduction
Bioactivity
英文名: Ibutamoren Mesylate
描述: Ibutamoren Mesylate (MK-0677) 是非肽段类生长激素促分泌素受体 (GHSR) 激动剂，也是一种口服有活性的生长激素 (GH) 促分泌素。
体内活性: Following oral administration Ibutamoren Mesylate(MK0677) amplifies episodic GH release.?Mechanistically, it synergizes with growth hormone releasing hormone (GHRH) through a receptor and signal transduction pathway distinct from that of GHRH and is a functional antagonist of somatostatin (SRIF).?MK0677 also acts on the arcuate nucleus and appears to stimulate GHRH release.?By using 35S-MK0677, a new G-protein coupled receptor for MK0677 was characterized in the plasma membrane fraction of pituitary and hypothalamic tissue.?The receptor is present in very low abundance and couples to phospholipase C. Other ligands selective for this receptor also cause synchronization of well-defined pathways leading to GH release.?Repeated oral treatment of dogs once daily with MK0677 initiates amplified pulsatile GH release accompanied by increases in IGF-1 that are sustained.?The unique biological properties of MK0677 and other synthetic ligands that bind to the same receptor force us to predict that these ligands mimic a naturally occurring hormone that regulates pulsatile GH release[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (80.03 mM)
关键字: MK0677 | MK677 | Inhibitor | Ibutamoren | inhibit | Growth hormone secretagogue receptor | GHSR | Ibutamoren Mesylate | MK 0677 | MK 677
相关产品: Cortistatin-8 acetate | Emoghrelin | Relamorelin | L-692429 | NF-56-EJ40 hydrochloride | PF-5190457 | CJC-1295 acetate(863288-34-0 free base) | JMV 2959 hydrochloride (925238-89-7 free base) | TC-G-1008 | Obestatin (rat) acetate
相关库: Drug Repurposing Compound Library | Anti-Cancer Drug Library | Clinical Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Anti-Cancer Clinical Compound Library | GPCR Compound Library | Orally Active Compound Library | NO PAINS Compound Library | Bioactive Compound Library
Bioactivity
英文名: Ibutamoren Mesylate
描述: Ibutamoren Mesylate (MK-0677) 是非肽段类生长激素促分泌素受体 (GHSR) 激动剂，也是一种口服有活性的生长激素 (GH) 促分泌素。
体内活性: Following oral administration Ibutamoren Mesylate(MK0677) amplifies episodic GH release.?Mechanistically, it synergizes with growth hormone releasing hormone (GHRH) through a receptor and signal transduction pathway distinct from that of GHRH and is a functional antagonist of somatostatin (SRIF).?MK0677 also acts on the arcuate nucleus and appears to stimulate GHRH release.?By using 35S-MK0677, a new G-protein coupled receptor for MK0677 was characterized in the plasma membrane fraction of pituitary and hypothalamic tissue.?The receptor is present in very low abundance and couples to phospholipase C. Other ligands selective for this receptor also cause synchronization of well-defined pathways leading to GH release.?Repeated oral treatment of dogs once daily with MK0677 initiates amplified pulsatile GH release accompanied by increases in IGF-1 that are sustained.?The unique biological properties of MK0677 and other synthetic ligands that bind to the same receptor force us to predict that these ligands mimic a naturally occurring hormone that regulates pulsatile GH release[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (80.03 mM)
关键字: MK0677 | MK677 | Inhibitor | Ibutamoren | inhibit | Growth hormone secretagogue receptor | GHSR | Ibutamoren Mesylate | MK 0677 | MK 677
相关产品: Cortistatin-8 acetate | Emoghrelin | Relamorelin | L-692429 | NF-56-EJ40 hydrochloride | PF-5190457 | CJC-1295 acetate(863288-34-0 free base) | JMV 2959 hydrochloride (925238-89-7 free base) | TC-G-1008 | Obestatin (rat) acetate
相关库: Drug Repurposing Compound Library | Anti-Cancer Drug Library | Clinical Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Anti-Cancer Clinical Compound Library | GPCR Compound Library | Orally Active Compound Library | NO PAINS Compound Library | Bioactive Compound Library
公司简介
TargetMol（陶术）作为一家全球性的生物医药领域高科技企业，我们致力于为高校、研究所、医院、企业等各类生物医药研发机构提供优质的产品和服务，为全球医药科学家更高效地完成科研工作助力。可提供20,000+种 抑制剂和激动剂 、800+种 化合物库 、19,000+种 天然产物 ，以及9,000+种 重组蛋白 、多种 多肽 、抗体 和 生命科学试剂盒 等。此外，在上海，TargetMol研发中心配备了 CADD & AIDD研究中心、药理实验室和药物化学合成 平台三大技术中心，可提供虚拟筛选、化合物活性测试、分子间结合力检测和化合物结构优化等技术服务，多方位满足用户的研发需求。
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