GNE-493
基本信息
产品名称：
GNE-493
英文名称：
GNE-493
国产/进口：
进口
产地/品牌：
美国/TargetMol
型号：
参考报价：
面议
销售商：
总点击数：
12
更新日期：
2025-05-27
产品类别：
性能参数
Product Introduction
Bioactivity
英文名: GNE-493
描述: GNE-493 是选择性的PI3K/mTOR 抑制剂，能够抑制 PI3Kα (IC50:3.4 nM)，PI3Kβ (IC50:12 nM)，PI3Kδ (IC50:16 nM)，PI3Kγ (IC50:16 nM) 和 mTOR (IC50:32 nM)。
体内活性: GNE-493 is examined in the human MCF7.1 breast cancer xenograft model that harbors a PI3Kα activating mutation. Mice bearing xenografts are dosed orally once daily with 10 mg/kg of GNE-493 for 21 continuous days. Similar to observations made in the PC3 prostate cancer xenograft model, 10 mg/kg of GNE-493 results in 73% tumor growth inhibition at day 21 when compared to vehicle control animals. When achieving comparable levels of drug exposure, GNE-493 shows a similar suppression of the PI3K pathway and consequently, a similar efficacy profile against MCF7.1 breast tumors
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 45 mg/mL (120.82 mM)
关键字: Mammalian target of Rapamycin | GNE493 | PI3K | Inhibitor | inhibit | Phosphoinositide 3-kinase | GNE-493 | GNE 493 | mTOR
相关产品: SKI V | Dalbergioidin | Quercetin Dihydrate | LY-294002 hydrochloride | Copanlisib dihydrochloride | GS-9901 | PI3Kδ-IN-14 | Polygalasaponin F | Physalin B | RLY-2608
相关库: PI3K-AKT-mTOR Compound Library | HIF-1 Signaling Pathway Compound Library | Pyroptosis Compound Library | Oxidation-Reduction Compound Library | Inhibitor Library | Kinase Inhibitor Library | Anti-Cancer Active Compound Library | Autophagy Compound Library | Reprogramming Compound Library | Bioactive Compound Library
Bioactivity
英文名: GNE-493
描述: GNE-493 是选择性的PI3K/mTOR 抑制剂，能够抑制 PI3Kα (IC50:3.4 nM)，PI3Kβ (IC50:12 nM)，PI3Kδ (IC50:16 nM)，PI3Kγ (IC50:16 nM) 和 mTOR (IC50:32 nM)。
体内活性: GNE-493 is examined in the human MCF7.1 breast cancer xenograft model that harbors a PI3Kα activating mutation. Mice bearing xenografts are dosed orally once daily with 10 mg/kg of GNE-493 for 21 continuous days. Similar to observations made in the PC3 prostate cancer xenograft model, 10 mg/kg of GNE-493 results in 73% tumor growth inhibition at day 21 when compared to vehicle control animals. When achieving comparable levels of drug exposure, GNE-493 shows a similar suppression of the PI3K pathway and consequently, a similar efficacy profile against MCF7.1 breast tumors
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 45 mg/mL (120.82 mM)
关键字: Mammalian target of Rapamycin | GNE493 | PI3K | Inhibitor | inhibit | Phosphoinositide 3-kinase | GNE-493 | GNE 493 | mTOR
相关产品: SKI V | Dalbergioidin | Quercetin Dihydrate | LY-294002 hydrochloride | Copanlisib dihydrochloride | GS-9901 | PI3Kδ-IN-14 | Polygalasaponin F | Physalin B | RLY-2608
相关库: PI3K-AKT-mTOR Compound Library | HIF-1 Signaling Pathway Compound Library | Pyroptosis Compound Library | Oxidation-Reduction Compound Library | Inhibitor Library | Kinase Inhibitor Library | Anti-Cancer Active Compound Library | Autophagy Compound Library | Reprogramming Compound Library | Bioactive Compound Library
公司简介
TargetMol（陶术）作为一家全球性的生物医药领域高科技企业，我们致力于为高校、研究所、医院、企业等各类生物医药研发机构提供优质的产品和服务，为全球医药科学家更高效地完成科研工作助力。可提供20,000+种 抑制剂和激动剂 、800+种 化合物库 、19,000+种 天然产物 ，以及9,000+种 重组蛋白 、多种 多肽 、抗体 和 生命科学试剂盒 等。此外，在上海，TargetMol研发中心配备了 CADD & AIDD研究中心、药理实验室和药物化学合成 平台三大技术中心，可提供虚拟筛选、化合物活性测试、分子间结合力检测和化合物结构优化等技术服务，多方位满足用户的研发需求。
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