Purvalanol B
基本信息
产品名称：
Purvalanol B
英文名称：
Purvalanol B
国产/进口：
进口
产地/品牌：
美国/TargetMol
型号：
参考报价：
面议
销售商：
总点击数：
32
更新日期：
2025-05-27
产品类别：
性能参数
Product Introduction
Bioactivity
英文名: Purvalanol B
描述: Purvalanol B (NG 95) 是选择性可逆的 ATP 竞争性 CDK 抑制剂。它在一系列其他蛋白激酶 (IC50>1000 nM) 中显示出对 CDK 的选择性。它抑制耐氯喹菌株 P. falciparum 的生长。
动物实验: A SYBR Green I parasite growth assay was used to measure the IC50 of Purvalanol B with P. falciparum (strain W2). Purvalanol B or DMSO control were applied to synchronized parasites 36 hours post invasion and parasites were incubated for 12 hours. Giemsa-stained blood smears were used to determine the effect of Purvalanol B on parasite growth, global quantitative proteomic analysis was used to examine differences in protein expression between Purvalanol B-treated and control parasites and results were confirmed by qPCR[1].
体内活性: Purvalanol B application decreases the ability of late-stage P.falciparum trophozoites to form multinucleated schizonts and up-regulates proteasome subunits and proteins that contribute to redox homeostasis, which may indicate an increase in oxidative stress as a result of inhibitor application[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 40 mg/mL (92.40 mM)
关键字: cdc2 | inhibit | cyclin | CDK2 | NG95 | CDK5 | Purvalanol B | CDK | Parasite | NG-95 | P. falciparum | ATP | Cyclin dependent kinase | Inhibitor | p35
相关产品: ML167 | CDK12-IN-2 | CDK2-IN-20 | Pinoresinol | PF-562271 besylate | GW779439X | CDK4/6-IN-2 | Avotaciclib | AZ1495 | PROTAC CDK9 Degrader-1
相关库: Anti-Aging Compound Library | Anti-Breast Cancer Compound Library | Cell Cycle Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Inhibitor Library | Anti-Parasitic Compound Library | Anti-Pancreatic Cancer Compound Library | Bioactive Compound Library
Bioactivity
英文名: Purvalanol B
描述: Purvalanol B (NG 95) 是选择性可逆的 ATP 竞争性 CDK 抑制剂。它在一系列其他蛋白激酶 (IC50>1000 nM) 中显示出对 CDK 的选择性。它抑制耐氯喹菌株 P. falciparum 的生长。
动物实验: A SYBR Green I parasite growth assay was used to measure the IC50 of Purvalanol B with P. falciparum (strain W2). Purvalanol B or DMSO control were applied to synchronized parasites 36 hours post invasion and parasites were incubated for 12 hours. Giemsa-stained blood smears were used to determine the effect of Purvalanol B on parasite growth, global quantitative proteomic analysis was used to examine differences in protein expression between Purvalanol B-treated and control parasites and results were confirmed by qPCR[1].
体内活性: Purvalanol B application decreases the ability of late-stage P.falciparum trophozoites to form multinucleated schizonts and up-regulates proteasome subunits and proteins that contribute to redox homeostasis, which may indicate an increase in oxidative stress as a result of inhibitor application[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 40 mg/mL (92.40 mM)
关键字: cdc2 | inhibit | cyclin | CDK2 | NG95 | CDK5 | Purvalanol B | CDK | Parasite | NG-95 | P. falciparum | ATP | Cyclin dependent kinase | Inhibitor | p35
相关产品: ML167 | CDK12-IN-2 | CDK2-IN-20 | Pinoresinol | PF-562271 besylate | GW779439X | CDK4/6-IN-2 | Avotaciclib | AZ1495 | PROTAC CDK9 Degrader-1
相关库: Anti-Aging Compound Library | Anti-Breast Cancer Compound Library | Cell Cycle Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Inhibitor Library | Anti-Parasitic Compound Library | Anti-Pancreatic Cancer Compound Library | Bioactive Compound Library
公司简介
TargetMol（陶术）作为一家全球性的生物医药领域高科技企业，我们致力于为高校、研究所、医院、企业等各类生物医药研发机构提供优质的产品和服务，为全球医药科学家更高效地完成科研工作助力。可提供20,000+种 抑制剂和激动剂 、800+种 化合物库 、19,000+种 天然产物 ，以及9,000+种 重组蛋白 、多种 多肽 、抗体 和 生命科学试剂盒 等。此外，在上海，TargetMol研发中心配备了 CADD & AIDD研究中心、药理实验室和药物化学合成 平台三大技术中心，可提供虚拟筛选、化合物活性测试、分子间结合力检测和化合物结构优化等技术服务，多方位满足用户的研发需求。
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