Recombinant Human TWEAK
产品编号:
AF-310-06
别名:
TNF-related weak inducer of apoptosis, TNFSF12, DR3LG, Apo3-Ligand
描述:
TWEAK belongs to the TNF
family of ligands and signals through TWEAKR also known as TNFRSF12A. TWEAK is expressed in a variety of tissues,
including the adult heart, pancreas, skeletal muscle, small intestine, spleen
and peripheral blood lymphocytes. TWEAK
has the ability to induce NFkB activation and chemokine secretion, and to exert
an apoptotic activity in certain cells, such as HT-29 human adenocarcinoma
cells when cultured in the presence of IFN-g. TWEAK also promotes
proliferation and migration of endothelial cells. Recombinant human TWEAK is a soluble 17.0 kDa
polypeptide (154 amino acid residues) comprising the TNF homologous region of
TWEAK and is generated by proteolytic processing of the full length membrane
anchored TWEAK protein. Manufactured using all non-animal reagents.
氨基酸序列:
MKGRKTRARR AIAAHYEVHP RPGQDGAQAG VDGTVSGWEE ARINSSSPLR YNRQIGEFIV TRAGLYYLYC QVHFDEGKAV YLKLDLLVDG VLALRCLEEF SATAASSLGP QLRLCQVSGL LALRPGSSLR IRTLPWAHLK AAPFLTYFGL FQVH
来源:
E.coli
纯度:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
生物活性:
Assay
#1: The ED50 as determined by the
dose-dependent stimulation of IL-8 production by human PBMC is less than 10
ng/ml.
Assay
#2: TWEAK
weakly induces the death of HT29 cells when cultured in the presence of
IFN-γ. The ED50 for this
effect is between 30-45 ng/ml.
原产国:
USA
仅用于研究。不适用于诊断或治疗。
