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Species Cross-reactivity  H,D,P,M,R
 

Key Application  ELISA,WB,ICC
 

Host  Mouse
 

Antibody type  Monoclonal antibody
 

Purified method  Affinity purified
 

Isotype  IgG1
 

Molecular Weight  102kDa
 

Sensitivity  This antibody detects endogenous levels of HK1 and does not cross-react with related proteins.
 

Immunogen  Purified recombinant humanHK1 protein fragments expressed in E.coli.
 

UniProt Number  P19367
 

GeneBank ID  NM_000188
 

Subcellular location  Mitochondrion outer membrane.
 

Formulation  Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol
 

Altername  HK I,glycolytic enzyme,hexokinase type I brain form hexokinase
 

Gene_symbol  HKI; HXK1; HK1-ta; HK1-tb; HK1-tc
 

UniPort summary Function  null
 

Entrez summary  Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein. [provided by RefSeq, Apr 2009]
 

Application Images :  
 

Western blot detection of HK1 in Hela&Jurkat cell lysates using HK1 antibody (1:10000 diluted). Predicted band size: 102kDa Observed band size: 102kDa

Immunocytochemistry stain of Hela using HK1 antibody (1:300).