AniRes2005(V3.5)动物肺功能分析系统用于测量动物肺功能的相关参数。如气道压力(P)、肺容积(V)、流速(F)、气道阻力 (RL、Re)、肺顺应性(Cdyn)、动物用力肺通气功能(FVC)、FEVx、FEVx/FVC%、MVV、PEF等，为呼吸生理及药理研究提供科学 准确的实验数据。适用于小鼠、大鼠、豚鼠等小动物和兔子、小狗、小猴子等大动物。
AniRes2005系统包括硬件、软件和相关技术文档。硬件部分包括体描箱、信号调理器（含USB采集器）、智能小动物呼吸机、负压器(用于用力肺功能 测量)等， 软件部分完成数据采集、实时计算、存储、回放分析、打印等功能。通过系统的协同工作，来很好地满足您的科研设计。
本系统主要用于慢性支气管炎、慢性阻塞性肺气肿、支气管哮喘、气管扩张和激发试验研究、呼吸药理研究的药物评价及一般药理学的研究。

已经有上千篇使用本系统的文献被SCI收录。
1、STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion. Mina  Yang,  Haojie Jiang, Chen Ding, Lin Zhang,          
Nan Ding, Guoming Li, Fei Zhang, Jing Wang, Liufu Deng, Junling Liu, Yanyan Xu. IMMUNITY(IF=43.474).20 March 2023.
2、PEAR1 regulates expansion of activated fibroblasts and deposition of extracellular matrix in pulmonary fibrosis. Yan Geng, Lin Li, Jie Yan, Kevin Liu, Aizhen Yang, Lin Zhang, Yingzhi Shen, Han Gao, Xuefeng Wu, Imre Noth, Yong Huang, Junling Liu & Xuemei Fan. nature communications(IF=17.694). 14 December 2022.
3、Fe-Curcumin Nanozyme-Mediated Reactive Oxygen Species Scavenging and Anti-Inflammation for Acute Lung Injury. Renyikun Yuan,Yuqing Li,Shan Han,Xinxin Chen,Jingqi Chen,Jia He,Hongwei Gao,Yang Yang, Shilin Yang,and Yu Yang. ACS Central Science(IF=18.728). 2022 Jan 26; 8(1): 10–21.
4、A Nanozymatic Solution to Acute Lung Injury. Xiaoman Duan and Biwu Liu. ACS Central Science(IF=18.728). Dec 28, 2021.
5、Nrf2 modulated the restriction of lung function via impairment of intrinsic autophagy upon real-ambient PM2.5 exposure. MenghuiJiang, DaochuanLi, JinmeiPiao, YantingLi, LipingChen,JianyuLi, DiankeYu,JingboPi, RongZhang, RuiChen, WenChen,YuxinZheng. Journal of Hazardous Materials(IF=14.224). 15 April 2021.
6、In vivo respiratory toxicology of cooking oil fumes: Evidence, mechanisms and prevention.YongshengMa, LinjingDeng,PingMa,YangWu, XuYang,FangXiao, QihongDeng. Journal of Hazardous Materials(IF=14.224). 15 January 2021.
7、Hederasaponin C Alleviates Lipopolysaccharide-Induced Acute Lung Injury In Vivo and In Vitro Through the PIP2/NF-κB/NLRP3 Signaling Pathway. Shan Han, Renyikun Yuan. Frontiers in Immunology(IF=8.786). 25 February 2022.
8、Maternal Exposure of BALB/c Mice to Indoor NO2 and Allergic Asthma Syndrome in Offspring at Adulthood with Evaluation of DNA Methylation Associated Th2 Polarization。Huifeng Yue,1 Wei Yan,1 Xiaotong Ji,1 Rui Gao,1 Juan Ma,2 Ziyu Rao,2 Guangke Li,1 and Nan Sang. Environmental Health Perspectives (IF=11.035). SEPTEMBER 2017, VOLUME 125, ISSUE 9
9、Direct in vivo application of induced pluripotent stem cells is feasible and can be safe. Meng Xiang1*, Meng Lu1. Theranostics(IF=11.6). 2019; 9(1):290-310. 
10、Within- and cross-tissue gene regulations were disrupted by PM2.5 nitrate exposure and associated with respiratory functions Author links open overlay panel. Jushan Zhang,  Xiaowen Shao e, Jia Chen f, Changhui Wang a, Ke Hao.Science of The Total Environment(IF=10.753). Volume 850, 1 December 2022.
11、NAT10 accelerates pulmonary fibrosis through N4-acetylated TGFB1-initiated epithelial-to-mesenchymal transition upon ambient fine particulate matter exposure 
.Shenshen Wu, Lijia Yin, Ke Han, Bo Jiang, Qingtao Meng, Michael Aschner , Xiaobo Li , Rui Chen. Environmental Pollution(IF=9.988). Volume 322, 1 April 2023.
12、A safe and effective mucosal RSV vaccine in mice  consisting of RSV phosphoprotein and flagellin variant.
Bali Zhao,  Jingyi Yang, Bing He,Shibo Jiang, Huimin Yan. Cell Reports(IF=9.995). Volume 36, Issue 3, 20 July 2021
13、Revealing consensus gene pathways associated with respiratory functions and disrupted by PM2.5 nitrate exposure at bulk tissue and single cell resolution. Jushan Zhang, , Lihong Fan, Jingkun Jiang, Changhui Wang , Ke Hao. Environmental Pollution(IF=9.988). Volume 280, 1 July 2021
14、Hederasaponin C Alleviates Lipopolysaccharide-Induced Acute Lung Injury In Vivo and In Vitro Through the PIP2/NF-κB/NLRP3 Signaling Pathway. Shan Han, Renyikun Yuan, Yushun Cui, Jia He, Qin-Qin Wang, Youqiong Zhuo, Shilin Yang and Hongwei Gao. Frontiers in Immunology(IF=8.786), 25 February 2022 
15、Ulinastatin activates haem oxygenase 1 antioxidant pathway and attenuates allergic inflammation. Dongmei Song,Geng Song,Yinghao Niu,Wei Song,Jiantao Wang,Lei Yu,Jianwang Yang,Xin Lv,Harry Steinberg,Shu Fang Liu,Baoshan Wang. British Journal of Pharmacology (IF=9.473) . 5 September 2014.
16、Surfaxin attenuates PM2.5-induced airway inflammation via restoring surfactant proteins in rats exposed to cigarette smoke.Xian Wen Sun ,Ji Min Shen, Qing Yun Li. Environmental Research(IF=8.431).Volume 203, January 2022.
17、Niclosamide Ethanolamine Salt Alleviates Idiopathic Pulmonary Fibrosis by Modulating the PI3K-mTORC1 Pathway. Xiaolin Pei, Fangxu Zheng. Cells(IF=7.666).  2022, 11(3), 346
18、Histone modification in the lung injury and recovery of mice in response to pm2.5 exposure. XiaoTong Ji, Nan Sang. Chemosphere(IF=8.943). 220(2019)127-136.
19、Discovery of a novel Pleuromutilin derivative as anti-IPF lead compound via high-throughput assay
20、Kun Zhang a 1, Jingjing Liang a 1, Ning Wang a, Ning Li a, Yurui Jiang a, Xiaohe Li a, Cheng Yang a, Honggang Zhou a, Guang Yang. European Journal of Medicinal Chemistry (IF=7.088).Volume 241, 5 November 2022.
21、Effects of chronic electronic cigarettes exposure in inducing respiratory function decline and pulmonary tissue injury – A direct comparison to combustible cigarettes. Jushan  Zhang,  Haoxiang Cheng, Mo Xue, Yuming Xiong, Yujie Zhu, Johan L.M. Björkegren, Zhongyang Zhang, Jia Chen, Zhiqiang Shi, Ke Hao.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY(IF=7.129).  Volume 249, 1 January 2023
22、Deficiency of interleukin-6 receptor ameliorates PM2.5 exposure-induced pulmonary dysfunction and inflammation but not abnormalities in glucose homeostasis
.Renzhen Peng, Wenhui Yang, Wenpu Shao, Yanyi Xu, Zhekang Ying.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY(IF=7.129). Volume 247, 1 December 2022.
23、 Ambient ozone, and urban PM2.5 co-exposure, aggravate allergic asthma via transient receptor potential vanilloid 1-mediated neurogenic inflammation.
Zongpei Lian , Xu Yang d, Yan Zeng, Jinquan Li.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY(IF=7.129).Volume 243, 15 September 2022
24、Probiotics ameliorates pulmonary inflammation via modulating gut microbiota and rectifying Th17/Treg imbalance in a rat model of PM2.5 induced lung injury. Yongcan Wu, Caixia Pei, Xiaomin Wang, Yilan Wang, Demei Huang, Shihua Shi, Zherui Shen, Shuiqin Li, Yacong He, Zhenxing Wang, Jianwei Wang. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY(IF=7.129). 
25、Maternal NO2 exposure disturbs the long noncoding RNA expression profile in the lungs of offspring in time-series patterns. Huifeng Yue, , Nan Sang.Ecotoxicology and Environmental Safety(IF=7.129). Volume 246, November 2022

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本系统运行WIN7和WIN10环境下。中文界面、功能强、稳定性好、操作简单。
本系统曾获“北京市科学技术进步奖”三等奖。