重组SARS-CoV-2 S1-RBD(His tag)(＞95%)

特别提示：包括重组SARS-CoV-2 S1-RBD(His tag)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组SARS-CoV-2 S1-RBD(His tag)
英文名称：Recombinant SARS-CoV-2 Spike Protein (RBD, His Tag)
产品货号：Q15505
产品规格：100μg

纯度：＞95% as determined by SDS-PAGE

内毒素：＜1.0 EU per μg of the protein as determined by the LAL method

生物活性：The SARS-CoV-2 Spike Protein (RBD,His Tag) can bind with Human ACE2 in functional ELISA assay.

蛋白构建：A DNA sequence encoding the SARS-CoV-2 Spike Protein (RBD) was expressed with a polyhistidine tag at the C-terminus.

表达宿主：Baculovirus-Insect Cells

预测N端：Arg

分子量：The recombinant SARS-CoV-2 Spike Protein (RBD,His Tag) consists of 234 amino acids and predicts a molecular mass of 26.54kDa.

缓冲液：
Lyophilized from sterile 20mM PB,300mM NaCl,pH7.0,10% glycerol
Please contact us for any concerns or special requirements.
Normally 5% - 8% trehalose,mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.

运输方式：
In general,recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid.They are shipped out with blue ice unless customers require otherwise.

稳定性&储存条件：
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃.It is recommended that the protein be aliquoted for optimal storage.Avoid repeated freeze-thaw cycles.

复溶：A hardcopy of COA with reconstitution instruction is sent along with the products.Please refer to it for detailed information.

背景资料：
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell.Known receptors bind S1 are ACE2,angiotensin-converting enzyme 2;DPP4,dipeptidyl peptidase-4;APN,aminopeptidase N;CEACAM,carcinoembryonic antigen-related cell adhesion molecule 1;Sia,sialic acid;O-ac Sia,O-acetylated sialic acid.The spike is essential for both host specificity and viral infectivity.The term "peplomer" is typically used to refer to a grouping of heterologous proteins on the virus surface that function together.The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process.It"s been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor.The spike protein is a large type I transmembrane protein containing two subunits,S1 and S2.S1 mainly contains a receptor binding domain (RBD),which is responsible for recognizing the cell surface receptor.S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses,as well as protective immunity.The main functions for the Spike protein are summarized as:Mediate receptor binding and membrane fusion;Defines the range of the hosts and specificity of the virus;Main component to bind with the neutralizing antibody;Key target for vaccine design;Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD),leading to a higher mortality rate.

根据您的关注的重组SARS-CoV-2 S1-RBD(His tag)(＞95%)，重组SARS-CoV-2 S1-RBD，Recombinant SARS-CoV-2 Spike Protein (RBD, His Tag)，重组His tag，重组SARS-CoV-2 RBD，重组SARS-CoV-2受体结合区，重组SARS-CoV-2 Spike Protein (RBD, His Tag)，您可能还对以下产品有需求：



名称：重组人肿瘤坏死因子配体超家族成员15(TNFSF15)
货号：JN0439
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Met1-Leu192表达纯化得来。

TNFSF15质量控制：＞95%(还原性SDS-PAGE)


TNFSF15制剂：冻干品

TNFSF15保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

TNFSF15复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于TNFSF15：
Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. TNFSF15 exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli and programmed cell death of proliferating cells. These activities are highly specific to endothelial cells. TNFSF15 is also able to regulate the expression of several important genes involved in angiogenesis. These findings are consistent with the view that TNFSF15 functions as an autocrine cytokine to inhibit angiogenesis and stabilize the vasculature.

关注重组SARS-CoV-2 S1-RBD(His tag)(＞95%)，重组SARS-CoV-2 S1-RBD，Recombinant SARS-CoV-2 Spike Protein (RBD, His Tag)，重组His tag，重组SARS-CoV-2 RBD，重组SARS-CoV-2受体结合区，重组SARS-CoV-2 Spike Protein (RBD, His Tag)的同时，为您推荐更多您可能感兴趣的产品：


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