Rabbit anti-CD8 Polyclonal Antibody

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概述

别名

CD8抗体;CD 8a; CD8 alpha chain; CD8; CD8 antigen alpha chain; CD8 antigen alpha polypeptide; CD8 antigen alpha polypepitide (p32); CD8a; CD8a antigen; CD8a molecule; CD8A_MOUSE; Leu 2; Leu2; Leu2 T lymphocyte antigen; MAL; OKT8 T cell antigen; OTTHUMP00000160760; OTTHUMP00000160764; OTTHUMP00000203528; OTTHUMP00000203721; p32; T cell antigen Leu2; T cell co receptor; T cell coreceptor; T cell surface glycoprotein CD8 alpha chain; T lymphocyte differential on antigen T8/Leu 2; T lymphocyte differentiation antigen T8/Leu2; T-cell surface glycoprotein CD8 alpha chain; T-lymphocyte differentiation antigen T8/Leu-2; T8 T cell antigen; Cd8a; Lyt-2; Lyt2,CD8

宿主

Rabbit

特异性

CD8

反应种属

Human, Mouse

应用

WB: 1:500-2000, IHC-F: 1:100-500, IHC-P: 1:100-500, IF: 1:100-500, FCM: 2ug/Test

分子量

Predicted molecular weight: 27kDa

免疫原

KLH conjugated synthetic peptide derived from mouse CD8(51-150/247)

性能

形式

Liquid

浓度

1mg/mL

纯化方法

affinity purified by Protein A

类型

Polyclonal Antibody

克隆号

IgG

同种型

IgG

储存/保存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

存储溶液

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

标记

Unlabeled

修饰

Unmodified

靶标

背景说明

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane anchored or secreted protein. [provided by RefSeq, May 2020]

组织特异性

Most prominently found in the gastrointestinal tract, skin, lung, and brain but not in liver.

细胞定位

PD1731

UniProt

研究领域

> Immunology → Adaptive Immunity → Regulatory T Cells
> Immunology → Adaptive Immunity → T Cells → CD
> Stem Cells → Hematopoietic Progenitors → Lymphoid → T Lymphocytic Lineage
> Stem Cells → Hematopoietic Progenitors → Myeloid → Dendritic Cell Lineage

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