葡糖脑苷脂
| Cat. Number |
1522
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| Chemical Name |
葡糖脑苷脂 Glucocerebrosides
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| CAS Number |
497155-61-0
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| Mol. Formula |
C40H75NO9
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| Mol. Weight |
714
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| Qty 1 |
5mg
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| Appearance |
solid
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| Application Notes |
98+%,TLC; identity confirmed by MS
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| Synonym |
Glucosylceramide; Ceramide beta-D-glucoside
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| Solubility |
chloroform/methanol, 2:1
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| Storage condition |
-20℃
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| References |
Application Notes: This cerebroside product is a glycosphingolipid containing a glucose attached to a ceramide (glucocerebroside) acylated with hydroxy and non-hydroxy fatty acids. It is a major constituent of skin lipids where it has an important role in lamellar body formation and in maintaining the water permeability barrier. Glucocerebroside is very important due to its function as the biosynthetic precursor of lactosylceramide and from there of most of the neutral oligoglycolipids and gangliosides.1 Glucocerebroside is the only glycosphingolipid that is found in plants, fungi, and animals and is one of the most abundant glycosphingolipids in plants. Due to the relatively high melting point of cerebrosides (much greater than physiological body temperature) they have a para-crystalline structure. Glucocerebrosides tend to be concentrated in the outer leaflet of the plasma membrane in lipid rafts. It has been reported that glucocerebrosides are essential for the activity of tyrosinase (a key enzyme in melanin biosynthesis), to elicit defense responses in plants, and to help the plasma membrane in plants to withstand stresses brought about by cold and drought. In Gaucher’s disease glucocerebrosides accumulate in the spleen, liver, lungs, bone marrow, and brain due to a deficiency of the enzyme glucocerebrosidase.2 This accumulation of glucocerebroside has been associated with chemotherapy resistance. Glucocerebroside has been shown to be able to modulate membrane traffic along the endocytic pathway.3 References: |
上海惠诚生物科技有限公司，成立于2010年，企业宗旨“惠质产品，挚诚服务”。惠诚生物自成立以来，一直致力于为客户提供一站式科学服务，产品覆盖设计开发全过程，提供实验室设计、实验室建设、仪器设备、耗材、试剂、技术服务等专项配套服务。上海惠诚生物按照客户的研发、生产和质量控制环节整合各种优质资源，优化资源组合，为客户提供整体解决方案。
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“不忘初心，砥砺前行”。 上海惠诚生物经过多年不懈努力，目前产品线包括：生命科学，分析化学，生化试剂和仪器耗材。客户遍布：生物医药，体外诊断，食品行业，石油化工，科研院校和研究所等领域。
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Abcam、AdooQ、ALPCO、Biolegend、Cytiva、Cayman、Dojindo、Immunostar、Invitrogen、Jackson、美天旎Miltenyi、Novoprotein近岸、Prozyme、R&D、SinoBiological义翘、Stratagene、SYSY、Thermo Fisher、Wako、Topoen
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Aladdin阿拉丁、Avanti、Broadpharm、Focus、Laysan、LKT、Macklin麦克林、Sigma、TCI、Thermo Fisher、vivitide
仪器耗材：
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2971670858
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