N-己酰基-D-神经鞘氨醇
| Cat. Number |
1900
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| Chemical Name |
N-己酰基-D-神经鞘氨醇 N-Hexanoyl-D-erythro-sphingosine
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| CAS Number |
124753-97-5
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| Mol. Formula |
C24H47NO3
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| Mol. Weight |
398
|
| Qty 1 |
10mg
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| Appearance |
solid
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| Application Notes |
98+%,TLC; identity confirmed by MS
|
| Synonym |
N-C6:0-D-erythro-Ceramide
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| Solubility |
ethanol, chloroform, DMSO (up to 5 mg/ml)
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| Storage condition |
-20℃
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| References |
Application Notes: Ceramide is a fatty acid amide of sphingosine. This product is a well-defined ceramide having a hexanoyl acyl group. Ceramide functions as a precursor in the synthesis of sphingomyelin, glycosphingolipids, and of free sphingosine and fatty acids. The sphingosine can be phosphorylated to form sphingosine-1-phosphate. Two of ceramide’s metabolites, sphingosine- 1-phosphate and glucosylceramide, produce cell proliferation and other cellular functions.1 Ceramide exerts numerous biological effects, including induction of cell maturation, cell cycle arrest, terminal cell differentiation, cell senescence, and cell death.2 Because of these effects ceramide has been investigated for its use in cancer treatment and many potential approaches to cancer therapy have been presented.3 Other effects include producing reactive oxygen in mitochondria (followed by apoptosis) and stimulating phosphorylation of certain proteins (especially mitogen activated protein). It also stimulates some protein phosphatases (especially protein phosphatase 2A) making it an important controller of protein activity. Ceramides with short side chains have been shown to enter easily into cells where they are biologically active. Short-chain ceramide-1-phosphates can stimulate DNA synthesis while this effect can be counteracted by short-chain ceramides. Treatment of cells with C6:0-ceramide has been shown to result in a significant increase in long chain ceramide levels due to the degradation of the short-chain ceramide and subsequent utilization of the liberated sphingosine for synthesis of long-chain ceramides.4 Short-chain ceramides also decrease the plasma membrane lipid order which is an important factor in lipid raft signal transduction. References: |
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