Human TIM-3 / HAVCR2 Protein
内毒素:
Less than 1.0 EU per μg by the LAL method.
纯度:
>95% as determined by SDS-PAGE.
活性:
Measured by its binding ability in a functional ELISA.Immobilized Human TIM-3, His Tag (Catalog # TM3-H5229) at 2 μg/mL (100 μL/well) can bind anti-TIM3 mAb with a linear range of 0.2-3 ng/mL.
产品背景:
Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.
产品描述:
Human TIM-3, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 20.7 kDa. The predicted N-terminus is Ser 22. The reducing (R) protein migrates as 28-48 kDa in SDS-PAGE due to glycosylation.
ACROBiosystems具有多系统蛋白表达能力，目前最具优势的是HEK Max人源细胞高效蛋白表达平台，除此之外还有大肠杆菌、酵母、昆虫细胞等表达系统。不仅如此，重点蛋白产品还具有多种属、多标签可供选择。其中最具特色的生物素标记蛋白获得了海内外用户的一致认可。
ACROBiosystems有着严格的质量控制体系及完善的客服流程，以确保客户满意度及产品认可度为宗旨。目前的业务已经遍及全球50多个国家和地区，并在北美、亚洲、欧洲等不同地区设立分支机构以便服务当地客户。
目前ACROBiosystems最具特色的产品系列有：
生物素标记蛋白（Biotinylated Proteins）
免疫检查点蛋白（Checkpoint Proteins）
Fc受体蛋白（Fc Receptor Family Proteins）
肿瘤药物靶点蛋白（Drug Target Proteins）
PD-1 [Biotinylated] : PD-L1抑制剂筛选ELISA试剂盒（PD-1 [Biotinylated] : PD-L1 Inhibitor Screening ELISA Assay Pair）
5-min单克隆抗体分型试剂盒（Five-Minute Mouse/Rat Isotyping Kit ）
细胞因子、培养基、纯化介质及核酸酶
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