重组人的IL-8
基本信息
产品名称：
重组人的IL-8
英文名称：
Recombinant Human IL-8
国产/进口：
进口
产地/品牌：
美国 Leinco
型号：
1.0 mg
参考报价：
销售商：
总点击数：
5467
更新日期：
2026-04-02
产品类别：
性能参数
1.产品名称：重组人的IL-8
2.英文名称：Recombinant Human IL-8
3.产地/品牌：美国 Leinco
4.国产/进口：进口
5.型号：1.0 mg
6.货号：I-576
7.详细描述：
背景：
白细胞介素-8 (IL-8)是由巨噬细胞和其他细胞类型如上皮细胞产生的趋化因子。它也是由内皮细胞合成的，内皮细胞将IL-8储存在储存囊泡中。IL-8是炎症反应的主要介质之一。这种趋化因子由几种细胞类型分泌。它是一种化学吸引剂，也是一种强有力的血管生成因子。IL-8基因被认为在细支气管炎的发病过程中起着重要作用。虽然中性粒细胞是IL-8的主要靶细胞，但也有相当广泛的细胞(内皮细胞、巨噬细胞、肥大细胞、角质形成细胞)对这种趋化因子作出反应。当第一次遇到抗原时，最初遇到它的细胞是吞噬该颗粒的巨噬细胞。在处理过程中，它们释放趋化因子，向其他免疫细胞发出信号，让它们进入炎症部位。IL-8就是这样一种趋化因子。它作为一种化学信号，在炎症部位吸引中性粒细胞，因此也被称为中性粒细胞趋化因子。白细胞介素-8常与炎症有关。例如，它被认为是银屑病的促炎介质。
来源: E. coli
分子量：重组人IL-8的分子量预测为Mr 8.9 kDa
物质状态：冻干
宿主: E. coli
规格：10 µg, 50 µg, 1 mg
配方：该重组蛋白0.2µm过滤和改良杜贝克磷酸盐缓冲盐水(1X PBS) pH 7.2 - 7.3的冻干，无钙,镁,或防腐剂。
纯度：SDS-PAGE法测定bb0 97%，银染法测定bb0 97%。
存储和稳定：这种冻干蛋白在-20°C至-70°C干燥保存6至12个月是稳定的。该蛋白经无菌重组后，可在2℃至8℃保存1个月，也可在-20℃至-70℃人工除霜冰箱中保存。避免重复冻融循环。有关具体批次的存储说明，请参阅产品说明书。
内毒素:：< 1.0欧盟/µg LAL确定的方法阻断:在体内阻断IFNb导致感染西尼罗病毒(WNV)的小鼠的死亡率增加，与IFNb-/-小鼠的易感性相似。克隆HDß-4A7循环半衰期的~ 14天。
蛋白加入号:P10145
N端序列:Ala23和Ser28
运输温度:该蛋白可在常温下运输。收到后，立即按照建议的温度储存。
生物活性:IL-8诱导髓过氧化物酶释放细胞松弛素b处理人中性粒细胞的能力决定了IL-8的生物学活性。预期的ED50 = 0.15 - -0.3µg /毫升。
每个研究人员应针对特定应用确定自己的最佳工作稀释倍数。
GeneBank:https://www.ncbi.nlm.nih.gov/gene?cmd=search&term=P10145
文献：1. Haraldsen G et al. (1998) J Exp Med. 188: 1751
更多信息登录www.leinco.com或者拨打热线010-51668388-8011，QQ:1793915448
英文说明
Recombinant Human IL-8
Alternate Names:
(Interleukin-8, CXCL8, MDNCE, Neutrophil Activating Factor (NAF), NAP-1 Fractalkine Mucin-Like Stalk, 3-10C, AMCF-I, GCP-1, GCP1, K60, LECT, LUCT, LYNAP, MDNCF, MONAP, AP1, SCYB8, TSG-1, B-ENAP)
Format:
(Purified No Carrier Protein)
I-576
Description
Background:
Interleukin-8 (IL-8) is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles. IL-8 is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. Gene of IL-8 is believed to play a role in the pathogenesis of bronchiolitis. While neutrophil granulocytes are the primary target cells of IL-8 there is a relative wide range of cells (endothelial cells, macrophages, mast cells, keratinocytes) responding to this chemokine, too. When first encountering an antigen, the primary cells to encounter it are the macrophages that phagocytose the particle. Upon processing, they release chemokines to signal other immune cells to come in to the site of inflammation. IL-8 is one such chemokine. It serves as a chemical signal that attracts neutrophils at the site of inflammation, and therefore is also known as Neutrophil Chemotactic Factor. Interleukin-8 is often associated with inflammation. As an example, it has been cited as a proinflammatory mediator in psoriasis.1
Details
Source
E. coli
Molecular Weight
The predicted molecular weight of Recombinant Human IL-8 is Mr 8.9 kDa.
State of Matter
Lyophilized
Host
E. coli
Sizes Available
10 µg, 50 µg, 1 mg
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity
>97% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Protein Accession #:
P10145
N-Terminal Sequence:
Ala23 & Ser28
Shipping Temperature:
This protein may be shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
Biological Activity
The biological activity of Human IL-8 was determined by its ability to induce myeloperoxidase release cytochalasin B-treated human neutrophils. The expected ED50=0.15-0.3 µg/ml.
Each investigator should determine their own optimal working dilution for specific applications
References
1. Haraldsen G et al. (1998) J Exp Med. 188: 1751
Related Products
Anti-Porcine IL-8 (Leinco Prod. No.: C1437)
Anti-Human IL-8-Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: I-260)
Recombinant Human IL-8 (Mucin) (Leinco Prod. No.: I-597)
Anti-Human IL-8 (Leinco Prod. No.: I-176)
2.英文名称：Recombinant Human IL-8
3.产地/品牌：美国 Leinco
4.国产/进口：进口
5.型号：1.0 mg
6.货号：I-576
7.详细描述：
| 货号 | I-576 |
| 英文名 | Recombinant Human IL-8 |
| 分子量 | Mr 8.9 kDa |
| 来源 | E. coli |
| 规格 | 10 µg, 50 µg, 1 mg |
| 货期 | 3-4周 |
| 保存 | 可常温运输，收到后20°C至-70°C |
| 官网 | www.leinco.com |
| 文献 | 1. Haraldsen G et al. (1998) J Exp Med. 188: 1751 |
背景：
白细胞介素-8 (IL-8)是由巨噬细胞和其他细胞类型如上皮细胞产生的趋化因子。它也是由内皮细胞合成的，内皮细胞将IL-8储存在储存囊泡中。IL-8是炎症反应的主要介质之一。这种趋化因子由几种细胞类型分泌。它是一种化学吸引剂，也是一种强有力的血管生成因子。IL-8基因被认为在细支气管炎的发病过程中起着重要作用。虽然中性粒细胞是IL-8的主要靶细胞，但也有相当广泛的细胞(内皮细胞、巨噬细胞、肥大细胞、角质形成细胞)对这种趋化因子作出反应。当第一次遇到抗原时，最初遇到它的细胞是吞噬该颗粒的巨噬细胞。在处理过程中，它们释放趋化因子，向其他免疫细胞发出信号，让它们进入炎症部位。IL-8就是这样一种趋化因子。它作为一种化学信号，在炎症部位吸引中性粒细胞，因此也被称为中性粒细胞趋化因子。白细胞介素-8常与炎症有关。例如，它被认为是银屑病的促炎介质。
来源: E. coli
分子量：重组人IL-8的分子量预测为Mr 8.9 kDa
物质状态：冻干
宿主: E. coli
规格：10 µg, 50 µg, 1 mg
配方：该重组蛋白0.2µm过滤和改良杜贝克磷酸盐缓冲盐水(1X PBS) pH 7.2 - 7.3的冻干，无钙,镁,或防腐剂。
纯度：SDS-PAGE法测定bb0 97%，银染法测定bb0 97%。
存储和稳定：这种冻干蛋白在-20°C至-70°C干燥保存6至12个月是稳定的。该蛋白经无菌重组后，可在2℃至8℃保存1个月，也可在-20℃至-70℃人工除霜冰箱中保存。避免重复冻融循环。有关具体批次的存储说明，请参阅产品说明书。
内毒素:：< 1.0欧盟/µg LAL确定的方法阻断:在体内阻断IFNb导致感染西尼罗病毒(WNV)的小鼠的死亡率增加，与IFNb-/-小鼠的易感性相似。克隆HDß-4A7循环半衰期的~ 14天。
蛋白加入号:P10145
N端序列:Ala23和Ser28
运输温度:该蛋白可在常温下运输。收到后，立即按照建议的温度储存。
生物活性:IL-8诱导髓过氧化物酶释放细胞松弛素b处理人中性粒细胞的能力决定了IL-8的生物学活性。预期的ED50 = 0.15 - -0.3µg /毫升。
每个研究人员应针对特定应用确定自己的最佳工作稀释倍数。
GeneBank:https://www.ncbi.nlm.nih.gov/gene?cmd=search&term=P10145
文献：1. Haraldsen G et al. (1998) J Exp Med. 188: 1751
更多信息登录www.leinco.com或者拨打热线010-51668388-8011，QQ:1793915448
英文说明
Recombinant Human IL-8
Alternate Names:
(Interleukin-8, CXCL8, MDNCE, Neutrophil Activating Factor (NAF), NAP-1 Fractalkine Mucin-Like Stalk, 3-10C, AMCF-I, GCP-1, GCP1, K60, LECT, LUCT, LYNAP, MDNCF, MONAP, AP1, SCYB8, TSG-1, B-ENAP)
Format:
(Purified No Carrier Protein)
I-576
Description
Background:
Interleukin-8 (IL-8) is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles. IL-8 is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. Gene of IL-8 is believed to play a role in the pathogenesis of bronchiolitis. While neutrophil granulocytes are the primary target cells of IL-8 there is a relative wide range of cells (endothelial cells, macrophages, mast cells, keratinocytes) responding to this chemokine, too. When first encountering an antigen, the primary cells to encounter it are the macrophages that phagocytose the particle. Upon processing, they release chemokines to signal other immune cells to come in to the site of inflammation. IL-8 is one such chemokine. It serves as a chemical signal that attracts neutrophils at the site of inflammation, and therefore is also known as Neutrophil Chemotactic Factor. Interleukin-8 is often associated with inflammation. As an example, it has been cited as a proinflammatory mediator in psoriasis.1
Details
Source
E. coli
Molecular Weight
The predicted molecular weight of Recombinant Human IL-8 is Mr 8.9 kDa.
State of Matter
Lyophilized
Host
E. coli
Sizes Available
10 µg, 50 µg, 1 mg
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity
>97% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Protein Accession #:
P10145
N-Terminal Sequence:
Ala23 & Ser28
Shipping Temperature:
This protein may be shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
Biological Activity
The biological activity of Human IL-8 was determined by its ability to induce myeloperoxidase release cytochalasin B-treated human neutrophils. The expected ED50=0.15-0.3 µg/ml.
Each investigator should determine their own optimal working dilution for specific applications
References
1. Haraldsen G et al. (1998) J Exp Med. 188: 1751
Related Products
Anti-Porcine IL-8 (Leinco Prod. No.: C1437)
Anti-Human IL-8-Biotin (Antigen Aff. Pur.) (Leinco Prod. No.: I-260)
Recombinant Human IL-8 (Mucin) (Leinco Prod. No.: I-597)
Anti-Human IL-8 (Leinco Prod. No.: I-176)
公司简介
普瑞麦迪（北京）实验室技术有限公司坐落于中关村科技园丰台园区，是致力于生命科学实验室整体解决方案的国家高新技术企业。公司秉承“持续创新、以人为本、服务至上、合作共赢”的理念，以“引进全球创新技术、创新产品、助力中国生命科学飞速发展”为使命；聚集了一批行业内的专业精英，包括杰出的留学归国研发和管理人员及国内优秀人才等一起构成公司的精英团队。公司集自主研发和引进国际顶尖技术产品为一体，主营产品涵盖生命科学、医学、环境生物学及化学等领域的高端仪器及试剂。
售后服务
普瑞麦迪公司是专业的流式细胞仪代理和服务商，产品涵盖细胞成像系统、流式细胞仪、分子生物学产品、常规实验室设备及试剂等众多产品。公司有完善的售前、售后、实验室技术团队，有充足的仪器配件、DEMO样机及优秀的技术人员,“服务为本”是普瑞麦迪公司一贯的工作理念。
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