甲苯磺酸索拉非尼 - BAY 43-9006 Nexavar
Sorafenib tosylate - BAY 43-9006 Nexavar
CAS 475207-59-1
C21H16ClF3N4O3.C7H8O3S
MW 637.03 Purity: >99%
Soluble in DMSO
Biological Activity:
Small molecule inhibitor of protein kinase, targeting the Raf/Mek/Erk pathway.
References: DJ Panka et al. The Raf Inhibitor BAY 43-9006 (Sorafenib) Induces Caspase-Independent Apoptosis in Melanoma Cells. Cancer Res 2006, 66(3), 1611-1619.
SM Wilhelm et al. BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis. Cancer Res. 2004, 64, 7099-7109.
SM Wilhelm et al. The novel Raf inhibitor Bay 43-9006 blocks signaling and proliferation in BRAF mutant and wildtype melanoma and colorectal tumor cell lines. Proc. Am. Assoc. Cancer Res. 2003, 44, 106609.
Chemical Name: 4-{4-[3-(4-Chloro-3-methyl-phenyl)-ureido]-phenoxy}-pyridine-2-carboxylic acid methylamide tosylate
Sorafenib | Raf inhibitor | Axon Medchem | Axon 1397 | BAY 43-9006 | Nexavar |
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Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis. |
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