PeproTech重组人sIL-6 Receptor α--性能参数，报价/价格，图片

基本信息

产品名称：

PeproTech重组人sIL-6 Receptor α

英文名称：

Human sIL-6 Receptor α (CHO cell derived)

国产/进口：

进口

产地/品牌：

美国/PeproTech

型号：

5ug/20ug/100ug/250u

参考报价：

询价

销售商：

美国PeproTech(派普泰克)公司

总点击数：

1021

更新日期：

2025-05-14

产品类别：

细胞生物学试剂

性能参数

Recombinant Human sIL-6 Receptor α (CHO cell derived)

Catalog Number:

200-06RC

Synonyms:

soluble IL-6 receptor alpha, B cell stimulatory factor-2, CD126

Description:

IL-6 mediates its biological effects through the type I IL-6 receptor system that consists of two chains, IL-6Rα and gp130. While the IL-6Rα chain is the binding component specific to IL-6, the gp130 chain only transmits signals of IL-6 when bound to IL-6Rα. The gp130 can also transmit signals from LIF, OSM, CNTF, IL-11 and CT-1 in conjunction with other receptor subunits. The low-affinity binding site for IL-6 is composed of IL-6Rα alone. IL-6Rα is expressed in a wide range of cells, including T cells, fibroblasts and macrophages. Soluble IL-6Rα, which consists of only the extracellular domain of the IL-6Rα chain, acts as an agonist of IL-6 activity at low concentrations. PeproTech's CHO cell-derived Recombinant Human sIL-6 Receptor α is a 37.9 kDa glycoprotein corresponding to 339 amino acid residues of the extracellular domain of IL-6Rα. As a result of glycosylation, Recombinant Human sIL-6 Receptor α migrates with an apparent molecular mass of approximately 57-70 kDa by SDS-PAGE gel, under reducing conditions.

AA Sequence:

LAPRRCPAQE VARGVLTSLP GDSVTLTCPG VEPEDNATVH WVLRKPAAGS HPSRWAGMGR RLLLRSVQLH DSGNYSCYRA GRPAGTVHLL VDVPPEEPQL SCFRKSPLSN VVCEWGPRST PSLTTKAVLL VRKFQNSPAE DFQEPCQYSQ ESQKFSCQLA VPEGDSSFYI VSMCVASSVG SKFSKTQTFQ GCGILQPDPP ANITVTAVAR NPRWLSVTWQ DPHSWNSSFY RLRFELRYRA ERSKTFTTWM VKDLQHHCVI HDAWSGLRHV VQLRAQEEFG QGEWSEWSPE AMGTPWTESR SPPAENEVST PMQALTTNKD DDNILFRDSA NATSLPVQD

Source:

CHO cells

Purity:

Greater than 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity:

Determined by its ability to intensify the IL-6 induced growth inhibition of mouse M1 cells. The expectedED₅₀ is ≤ 5.0 ng/ml, in the presence of 20 ng/ml of rhIL-6.

Research Interests:

	Immune System		Inflammation
	Neurobiology		Receptors
	Stem Cells & Differentiation

Country of Origin:

USA

公司简介

PeproTech Inc. 创立于1988年，始终致力于为生命科学研究开发重组蛋白及相关产品，如今已成为能提供多种高质量细胞因子和重组蛋白，相应的单克隆、多克隆和生物素标记抗体，以及ELISA试剂盒的世界领导者。PeproTech Inc.的产品涵盖免疫调节蛋白、白介素、集落刺激因子、生长因子、化学趋化因子、干扰素、脂联素、成纤维生长因子、转化生长因子、肿瘤坏死因子、神经营养素和防御素等诸多生命科学研究领域中重要的生物活性分子。

为跟踪当今科研发展、满足日益增长的需求，PeproTech Inc.研制出无动物成分的重组蛋白(animal-free recombinant proteins)。有效地避免了动物源性污染引发潜在问题的可能性，从而可以应用于临床前研究和细胞治疗。此外，PeproTech Inc.最新还开发出无动物成分的培养基添加物试剂盒(animal-free Media Supplement Kits)。这些试剂盒经改良设计，其中的无血清组分对多种哺乳动物细胞的生长有更好的维持能力。

PeproTech Inc.的产品自2000年进入中国市场以来，以其优良的品质和合理的价格迅速得到国内各重点研究和实验机构的认可和青睐。鉴于中国经济发展的良好态势和中国生物医药研发投入的巨额增长，PeproTech Inc.于2009年10月在中国苏州设立代表机构，意为中国的广大用户提供更好的支持和服务，并助中国的科研和产业开发一臂之力。

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