促肾上腺皮质激素ACTH(18-39)抗体--性能参数，报价/价格，图片

基本信息

产品名称：

促肾上腺皮质激素ACTH(18-39)抗体

英文名称：

ACTH (18-39)

国产/进口：

国产

产地/品牌：

bioss

型号：

bs-0442R

参考报价：

销售商：

北京博奥森生物技术有限公司

总点击数：

750

更新日期：

2017-05-03

产品类别：

抗体

性能参数

产品编号	bs-0442R
英文名称	ACTH (18-39)
中文名称	促肾上腺皮质激素ACTH(18-39)抗体
别名	Adrenocorticotropic hormone; Adrenocorticotropin; Adrenocorticotropin Hormone; Alpha Melanocyte Stimulating Hormone; Beta Lipotropin; Beta Melanocyte Stimulating Hormone; CLIP; Corticotropin; Corticotropin Like Intermediary Peptide; Corticotropin lipotropin precursor; Lipotropin Beta; Lipotropin Gamma; LPH; Melanotropin Alpha; Met Enkephalin; MSH; NPP; POC; POMC; Pro opiomelanocortin; Proopiomelanocortin; COLI_HUMAN.
规格价格	0.1ml/580元购买 0.2ml/960元购买
说明书	0.1ml 0.2ml
研究领域	肿瘤神经生物学信号转导生长因子和激素内分泌病
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human,
产品应用	ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	2.5/4.5kDa
性状	Lyophilized or Liquid
浓度	1mg/1ml
免疫原	KLH conjugated synthetic peptide derived from human ACTH(18-
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
生产商	BIOSS
PubMed	PubMed
产品介绍	background: This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]. Function: ACTH stimulates the adrenal glands to release cortisol. MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes. Beta-endorphin and Met-enkephalin are endogenous opiates. Subcellular Location: Secreted. Tissue Specificity: ACTH and MSH are produced by the pituitary gland. Post-translational modifications: Specific enzymatic cleavages at paired basic residues yield the different active peptides. O-glycosylated; reducing sugar is probably N-acetylgalactosamine. DISEASE: Defects in POMC may be associated with susceptibility to obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Defects in POMC are the cause of pro-opiomelanocortinin deficiency (POMCD) [MIM:609734]. Affected individuals present early-onset obesity, adrenal insufficiency and red hair. Similarity: Belongs to the POMC family. Gene ID: 5443 Database links: Entrez Gene: 5443 Human Entrez Gene: 18976 Mouse Entrez Gene: 24664 Rat Omim: 176830 Human SwissProt: P01189 Human SwissProt: P01193 Mouse SwissProt: P01194 Rat Unigene: 1897 Human Unigene: 277996 Mouse Unigene: 108195 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 促肾上腺皮质激素(Adrenorticotrophin hormons, ACTH)是垂体前叶细胞分泌的一种多肽激素，是肾上腺皮质活性的主要调节者。此抗体可与人的ACTH反应,与多种其它哺乳动物的ACTH有交叉反应，可用于垂体腺瘤的功能性分类，有助于区分原发性和转移型垂体肿瘤，嗜络细胞瘤等部分神经内分泌肿瘤也可出现阳性反应.

公司简介

北京博奥森生物技术有限公司成立于2001年，注册资本2000万元，是集免疫学科研试剂研发、生产、销售为一体的国家高新技术企业。在公司近1300平米的研发中心楼内，拥有SPF级实验动物房、GMP级单克隆抗体制备平台，同时购置了CSBio多肽合成仪、Akta全自动液相色谱系统、BD流式细胞仪、Leica冷冻切片机等多种生产、检测仪器。公司还拥有一批技术精湛、经验丰富的科研开发团队，在免疫和分子生物学等领域拥有多项自主知识产权。

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